caa a22 4500 465753485 CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF01600106 doi (NATIONALLICENCE)springer-10.1007/BF01600106 Differing microvasculature in the two major types of gastric carcinoma: a conventional, ultrastructural and ultrastructural immunolocalization study of von Willebrand factor [Elektronische Daten] [Haruo Ohtani, Hiroshi Nagura] Summary: The microvasculature of the stroma of human gastric carcinoma was studied by immuno-electron microscopy for factor VIII/von Willebrand factor (vWF) and conventional electron microscopy. In differentiated type (intestinal) gastric carcinoma (9 cases), capillaries were distributed more densely around carcinoma cell nests. vWF was localized in endothelial cells and neighbouring stroma. Ultrastructurally, capillary endothelial cells showed considerable hypertrophic changes with well-developed rough endoplasmic reticulum (rER). vWF was localized in well-developed rER, granules, Weibel-Palade bodies (WPB), in the vascular lumen as clusters, and diffusely deposited in the subendothelium. This indicates that endothelial cells in this group are transformed into a state of active protein production. In undifferentiated type (diffuse) gastric carcinoma (12 cases), capillaries were uniformly distributed and endothelial hypertrophic changes were less remarkable. vWF was localized in WPB, scanty rER and subendothelial matrix. Solid capillary buds were observed in both types; they were composed of a solid strand of endothelial cells without a visible lumen. Our results reveal that the microvasculature in tumour stroma differs significantly according to its histological type. Springer-Verlag, 1990 Gastric carcinoma nationallicence Capillaries nationallicence von Willebrand factor nationallicence Ultrastructure nationallicence Immuno-electron microscopy nationallicence Ohtani Haruo Department of Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ward, 980, Sendai, Japan aut Nagura Hiroshi Department of Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ward, 980, Sendai, Japan aut Virchows Archiv A Springer-Verlag 417/1(1990-01-01), 29-35 0174-7398 417:1<29 1990 417 428 https://doi.org/10.1007/BF01600106 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01600106 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohtani Haruo Department of Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ward, 980, Sendai, Japan aut NATIONALLICENCE 700 1- Nagura Hiroshi Department of Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ward, 980, Sendai, Japan aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/1(1990-01-01), 29-35 0174-7398 417:1<29 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer