caa a22 4500 465753507 CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF01600111 doi (NATIONALLICENCE)springer-10.1007/BF01600111 Placental alkaline phosphatase in developing normal and abnormal gonads and in germ-cell tumours [Elektronische Daten] [Jean Hustin, Yves Gillerot, Julien Collette, Paul Franchimont] Summary: The evolution of the gonads during intra-uterine development has been followed by immunohistochemical demonstration of placental-like alkaline phosphatase (PLAP) at the germ-cell level. PLAP immunopositivity was restricted to the limited period when germ cells were not surrounded by granulosa or Sertoli cells. Abnormal fetuses or neonates presenting with chromosomal anomalies frequently had disorganized gonads where germ cells retained their membrane PLAP immunopositivity. This abnormal immunopositivity is similar to that expressed by abnormal germ cells in testicular in situ carcinoma, in gonadoblastoma (case of 45,XO/ 46,XY mosaic) and in seminoma. The pattern of positivity for other germ-cell tumours was highly variable. We suggest that in abnormal gonads, dysgenetic or neoplastic, an early embryonic property is retained by abnormal germ cells. Its importance in the process of neoplastic induction remains to be defined. Springer-Verlag, 1990 Placental alkaline phosphatase nationallicence Germ cells nationallicence Embryo nationallicence Chromosome anomalies nationallicence Germcell tumours nationallicence Hustin Jean Institute of Pathology, Allée des Templiers 41, B-6280, Loverval, Belgium aut Gillerot Yves Institute of Pathology, Allée des Templiers 41, B-6280, Loverval, Belgium aut Collette Julien Radioimmunology Department, University of Liege, Belgium aut Franchimont Paul Radioimmunology Department, University of Liege, Belgium aut Virchows Archiv A Springer-Verlag 417/1(1990-01-01), 67-72 0174-7398 417:1<67 1990 417 428 https://doi.org/10.1007/BF01600111 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01600111 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hustin Jean Institute of Pathology, Allée des Templiers 41, B-6280, Loverval, Belgium aut NATIONALLICENCE 700 1- Gillerot Yves Institute of Pathology, Allée des Templiers 41, B-6280, Loverval, Belgium aut NATIONALLICENCE 700 1- Collette Julien Radioimmunology Department, University of Liege, Belgium aut NATIONALLICENCE 700 1- Franchimont Paul Radioimmunology Department, University of Liege, Belgium aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/1(1990-01-01), 67-72 0174-7398 417:1<67 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer