caa a22 4500 465753523 CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF01600109 doi (NATIONALLICENCE)springer-10.1007/BF01600109 Morphometrical analysis of gall-bladder adenoma and adenocarcinoma with reference to histogenesis and adenoma-carcinoma sequence [Elektronische Daten] [Susumu Nakajo, Masami Yamamoto, Eiichi Tahara] Summary: In order to examine whether our subdivision of gall-bladder adenoma and adenocarcinoma into nonmetaplastic and metaplastic types is reasonable from the viewpoint of their cytological features, a morphometrical analysis was conducted on 17 adenomas and 59 adenocarcinomas. The morphometrical parameters used were nucleo-cytoplasmic ratio (N/C ratio) and nuclear areas (NA). N/C ratio in the metaplastic type of both adenoma and adenocarcinoma was significantly larger than that in the non-metaplastic. This result shows that the different tumour types are associated with a different N/C ratio. Continuous measurement of N/C ratio and NA in progressing from non-cancerous mucosa to the lesion was made and the data obtained were analysed by the Lowess method. In some adenomas the total area of polypoid lesions was serially measured and these data were also analysed by the Lowess method. The results showed different processes in non-metaplastic and metaplastic types of adenoma and adenocarcinoma from the standpoint of nuclear changes of N/C ratio and NA. These results indicate that our histogenetic classification of adenocarcinoma is reasonable in morphometrical nuclear analysis. We also investigated the adenoma-carcinoma sequence as a possible histogenesis for gall-bladder carcinoma. Eight (72.7%) of 11 metaplastic adenomas and two (33.3%) of six non-metaplastic adenomas had foci of atypical gland proliferation and were considered to be carcinomas. Moreover, these carcinomatous areas were surrounded by severe dysplasia. These findings indicate that adenoma-carcinoma sequence accounts for one of the histogeneses of gall-bladder carcinoma. Springer-Verlag, 1990 Morphometry nationallicence Gall-bladder nationallicence Adenoma nationallicence Adenocarcinoma nationallicence Histogenesis nationallicence Adenoma-carcinoma sequence nationallicence Nakajo Susumu Department of Pathology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut Yamamoto Masami Division of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan aut Tahara Eiichi Department of Pathology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut Virchows Archiv A Springer-Verlag 417/1(1990-01-01), 49-56 0174-7398 417:1<49 1990 417 428 https://doi.org/10.1007/BF01600109 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01600109 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakajo Susumu Department of Pathology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut NATIONALLICENCE 700 1- Yamamoto Masami Division of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan aut NATIONALLICENCE 700 1- Tahara Eiichi Department of Pathology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, 734, Hiroshima, Japan aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/1(1990-01-01), 49-56 0174-7398 417:1<49 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer