caa a22 4500 465753574 CHVBK 20180323111840.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF01600105 doi (NATIONALLICENCE)springer-10.1007/BF01600105 Diagnosis of primary cerebral lymphoma with particular reference to CT-guided stereotactic biopsy [Elektronische Daten] [Wolfgang Feiden, Karl Bise, Ulrich Steude] Summary: In establishing the histological diagnosis of primary cerebral lymphoma, stereotactic brain tumour biopsy is the method of choice as the mainstay of therapy is radiation and chemotherapy. This study describes the histopathology and diagnostic immunohistochemistry of 54 primary brain lymphomas in a mainly non-AIDS population. The stereotactic biopsies were performed using the Leksell CT stereotactic frame and a spiral needle which procured about 10-mm-long tissue cylinders. Usually, three successive biopsy cylinders were taken along the target trajectory. Histological examination revealed the prevalence of high-grade non-Hodgkin's lymphoma of the polymorphous centroblastic type. The series did not include any low-grade lymphomas or T-cell lymphomas. L-26 immunohistochemistry resulted in a positive staining of the blasts, thus confirming the B-cell origin of primary brain lymphomas. Small reactive T-lymphocytes and monohistiocytic cells were also found within and at the periphery of the lymphomas and in areas of degeneration. In the biopsies of nine patients, who had shown significant reduction of the lesions on the CT scans, after corticosteroid medication, regressive tissue changes were predominant and consisted of T-lymphocytes, macrophages, and occasionally bizarre reactive astrocytes. Springer-Verlag, 1990 Non-Hodgkin's lymphoma nationallicence Brain neoplasm nationallicence Stereotactic brain biopsy nationallicence Histological diagnosis nationallicence Immunohistochemistry nationallicence Feiden Wolfgang Institut für Neuropathologie, Thalkirchner Strasse 36, D-8000, Munich, Germany aut Bise Karl Institut für Neuropathologie, Thalkirchner Strasse 36, D-8000, Munich, Germany aut Steude Ulrich Neurochirurgische Klinik, Ludwig-Maximilians-UniversitÄt München, Klinikum Gro\hadern, Marchioninistrasse 13, D-8000, Munich, Germany aut Virchows Archiv A Springer-Verlag 417/1(1990-01-01), 21-28 0174-7398 417:1<21 1990 417 428 https://doi.org/10.1007/BF01600105 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01600105 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Feiden Wolfgang Institut für Neuropathologie, Thalkirchner Strasse 36, D-8000, Munich, Germany aut NATIONALLICENCE 700 1- Bise Karl Institut für Neuropathologie, Thalkirchner Strasse 36, D-8000, Munich, Germany aut NATIONALLICENCE 700 1- Steude Ulrich Neurochirurgische Klinik, Ludwig-Maximilians-UniversitÄt München, Klinikum Gro\hadern, Marchioninistrasse 13, D-8000, Munich, Germany aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/1(1990-01-01), 21-28 0174-7398 417:1<21 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer