caa a22 4500 465753590 CHVBK 20180323111841.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF01600102 doi (NATIONALLICENCE)springer-10.1007/BF01600102 von Hochstetter A. Department of Pathology, University Hospital and the Orthopaedic University Clinic Balgrist, Zurich, Switzerland aut Spontaneous necrosis in osteosarcomas [Elektronische Daten] [A. von Hochstetter] Summary: In the treatment of osteosarcoma pre-operative chemotherapy has assumed considerable importance in helping improve survival, and enabling limb-sparing procedures. The quantitative assessment of tumour necrosis in the resected specimen by morphological means has become a significant step in judging therapeutic response and in helping determine post-operative management. Different systems of grading tumour regression have been proposed. Little is known, however, about the morphology or degree of spontaneous necrosis in osteosarcomas, in particular to what extent necrosis can be considered to be due to cytotoxic treatment. For this purpose, 13 osteosarcomas, taken from patients treated by surgery alonge, were examined by the same method we routinely employ in assessing chemotherapeutic response. The results demonstrate that the extent of spontaneous necrosis does not approach that achieved in response to chemotherapy. Sub-total necrosis may be due to spontaneous regression, inadequate therapeutic response, or to a combination of both. Hence, only two categories of response, good and poor, appear relevant and these terms should be used in preference to good, intermediate and poor. Springer-Verlag, 1990 Osteosarcoma nationallicence Necrosis nationallicence Surgery, operative nationallicence Drug therapy, chemotherapy nationallicence Virchows Archiv A Springer-Verlag 417/1(1990-01-01), 5-8 0174-7398 417:1<5 1990 417 428 https://doi.org/10.1007/BF01600102 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01600102 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- von Hochstetter A. Department of Pathology, University Hospital and the Orthopaedic University Clinic Balgrist, Zurich, Switzerland aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/1(1990-01-01), 5-8 0174-7398 417:1<5 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer