caa a22 4500 465753620 CHVBK 20180323111841.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF01625725 doi (NATIONALLICENCE)springer-10.1007/BF01625725 Occurrence and prevention of contraction bands in Purkinje fibres, transitional cells and working myocardium during global ischaemia [Elektronische Daten] [Ph. Schnabel, A. Schmiedl, B. Ramsauer, U. Bartels, M. Gebhard, J. Richter, H. Bretschneider] Summary: Contraction bands usually occur in the intramural working myocardium following post-ischaemic reperfusion. In the subendocardium, however, they are found during ischaemia. Thus, we ascertained the contraction states of Purkinje fibres, transitional cells, subendocardial and intramural parts of the working myocardium during 30 min global ischaemia at 25° C. The effects with and without myocardial protection were compared. At the onset of pure ischaemia contraction bands are completely lacking in all cell types. During pure ischaemia contraction bands are found in all subendocardial cell types but not in the intramural working myocardium. A peak of pathological contraction states is found in the intramural working myocardium at the onset (0 min), in the subendocardial working myocardium at 10 min, in the transitional cells and Purkinje fibres at 30 min of pure ischaemia. Histidine-, tryptophan-, ketoglutarate-enriched (HTK) cardioplegia prevents contraction bands completely at the onset of ischaemia and prevents both contraction bands and pathological contraction states during ischaemia almost completely. Striking differences in the physiological contraction states are seen only in the working myocardium: HTK cardioplegia brings about dominance of relaxation during ischaemia. These findings may be due mainly to the effects of global ischaemia on the one hand and to catecholamines, calcium and oxygen on the other. Springer-Verlag, 1990 Purkinje fibres nationallicence Transitional cells nationallicence Working myocardium nationallicence Global ischaemia nationallicence Ultrastructure nationallicence Contraction state nationallicence Schnabel Ph Abteilung Vegetative Physiologie und Pathophysiologie, Zentrum Physiologie und Pathophysiologie, Deutschland aut Schmiedl A. Abteilung Vegetative Physiologie und Pathophysiologie, Zentrum Physiologie und Pathophysiologie, Deutschland aut Ramsauer B. Abteilung Vegetative Physiologie und Pathophysiologie, Zentrum Physiologie und Pathophysiologie, Deutschland aut Bartels U. Abteilung Vegetative Physiologie und Pathophysiologie, Zentrum Physiologie und Pathophysiologie, Deutschland aut Gebhard M. Abteilung Vegetative Physiologie und Pathophysiologie, Zentrum Physiologie und Pathophysiologie, Deutschland aut Richter J. Abteilung Elektronenmikroskopie, Zentrum Anatomie, Universität Göttingen, Göttingen, Federal Republic of Germany aut Bretschneider H. Abteilung Vegetative Physiologie und Pathophysiologie, Zentrum Physiologie und Pathophysiologie, Deutschland aut Virchows Archiv A Springer-Verlag 417/6(1990-11-01), 463-471 0174-7398 417:6<463 1990 417 428 https://doi.org/10.1007/BF01625725 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01625725 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schnabel Ph Abteilung Vegetative Physiologie und Pathophysiologie, Zentrum Physiologie und Pathophysiologie, Deutschland aut NATIONALLICENCE 700 1- Schmiedl A. Abteilung Vegetative Physiologie und Pathophysiologie, Zentrum Physiologie und Pathophysiologie, Deutschland aut NATIONALLICENCE 700 1- Ramsauer B. Abteilung Vegetative Physiologie und Pathophysiologie, Zentrum Physiologie und Pathophysiologie, Deutschland aut NATIONALLICENCE 700 1- Bartels U. Abteilung Vegetative Physiologie und Pathophysiologie, Zentrum Physiologie und Pathophysiologie, Deutschland aut NATIONALLICENCE 700 1- Gebhard M. Abteilung Vegetative Physiologie und Pathophysiologie, Zentrum Physiologie und Pathophysiologie, Deutschland aut NATIONALLICENCE 700 1- Richter J. Abteilung Elektronenmikroskopie, Zentrum Anatomie, Universität Göttingen, Göttingen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Bretschneider H. Abteilung Vegetative Physiologie und Pathophysiologie, Zentrum Physiologie und Pathophysiologie, Deutschland aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/6(1990-11-01), 463-471 0174-7398 417:6<463 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer