caa a22 4500 465753639 CHVBK 20180323111841.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF01625728 doi (NATIONALLICENCE)springer-10.1007/BF01625728 Reticulin fibre content of bone marrow infiltrates of malignant non-Hodgkin's lymphomas (B-cell type, low malignancy) — a morphometric evaluation before and after therapy [Elektronische Daten] [Juergen Thiele, Joerg Langohr, Markus Skorupka, Robert Fischer] Summary: A morphometric study was performed on bone marrow infiltrates of non-Hodgkin's lymphomas (B-cell type, low malignancy) to evaluate the content of argyrophilic (reticulin) fibres in the various subtypes before and after therapy. In congruence with the corresponding lymph node lesions, subtypes consisted of lymphocytic lymphoma — chronic lymphocytic leukaemia (CLL,n = 39), centroblastic-centrocytic lymphoma (CB-CC,n = 35), lymphoplasmacytoid immunocytoma (LPI,n = 22) and finally hairy cell leukaemia (HCL,n = 21). In comparison with control specimens, morphometric measurements on trephine biopsies (initial staging procedure) disclosed a borderline or minimal increase in reticulin in CLL and moderate fibrosis in CB-CC and LPI, whereas HCL had the greatest increase in fibres. The marrow surrounding focal or patchy lymphoma infiltrates of CLL and CB-CC displayed no relevant changes in fibre density with respect to the control samples. Following chemotherapy, repeated trephine biopsies (restaging procedure) were obtainable from 38 patients. There was no significant decrease in the fibre content of CLL, CB-CC and LPI infiltrates. In HCL an incomplete reduction was recorded after interferon treatment. So-called benign lymphoid lesions may be distinguished from focal-patchy infiltrates of CB-CC and LPI not only by showing a central localization, but also by the absence of significant amounts of reticulin. However, considering the density of the reticulin fibres, a clear-cut discrimination of these lymphoid aggregates from an early nodal-central growth pattern of CLL is not feasible in many cases. Springer-Verlag, 1990 Argyrophilic (reticulin) fibres nationallicence Malignant non-Hodgkin's lymphomas nationallicence Bone marrow infiltrates nationallicence Benign lymphoid lesions nationallicence Morphometry nationallicence Thiele Juergen Institute of Pathology, University of Cologne, Joseph-Stelzmann-Strasse 9, W-5000, Cologne 41, Federal Republic of Germany aut Langohr Joerg Institute of Pathology, University of Cologne, Joseph-Stelzmann-Strasse 9, W-5000, Cologne 41, Federal Republic of Germany aut Skorupka Markus Institute of Pathology, University of Cologne, Joseph-Stelzmann-Strasse 9, W-5000, Cologne 41, Federal Republic of Germany aut Fischer Robert Institute of Pathology, University of Cologne, Joseph-Stelzmann-Strasse 9, W-5000, Cologne 41, Federal Republic of Germany aut Virchows Archiv A Springer-Verlag 417/6(1990-11-01), 485-492 0174-7398 417:6<485 1990 417 428 https://doi.org/10.1007/BF01625728 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01625728 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thiele Juergen Institute of Pathology, University of Cologne, Joseph-Stelzmann-Strasse 9, W-5000, Cologne 41, Federal Republic of Germany aut NATIONALLICENCE 700 1- Langohr Joerg Institute of Pathology, University of Cologne, Joseph-Stelzmann-Strasse 9, W-5000, Cologne 41, Federal Republic of Germany aut NATIONALLICENCE 700 1- Skorupka Markus Institute of Pathology, University of Cologne, Joseph-Stelzmann-Strasse 9, W-5000, Cologne 41, Federal Republic of Germany aut NATIONALLICENCE 700 1- Fischer Robert Institute of Pathology, University of Cologne, Joseph-Stelzmann-Strasse 9, W-5000, Cologne 41, Federal Republic of Germany aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/6(1990-11-01), 485-492 0174-7398 417:6<485 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer