caa a22 4500 465753663 CHVBK 20180323111841.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF01625730 doi (NATIONALLICENCE)springer-10.1007/BF01625730 Vascular hepatotoxicity related to heroin addiction [Elektronische Daten] [Maria de Araújo, Françoise Gerard, Philippe Chossegros, Luís Porto, Pierre Barlet, Jean-Alexis Grimaud] Summary: The hepatotoxic effect of heroin has been demonstrated in liver biopsies by morphometric analysis of four groups of patients: twenty-one drug abusers (DA) at the time of the biopsy, eighteen patients who had stopped drug consumption for at least six months (ex-DA), twelve patients with post-transfusional chronic active hepatitis (PTCAH), and eleven controls (CONTROL). Semiquantitative assessment showed the extent of sinusoidal dilatation and the inflammatory and fibrotic reaction in the terminal hepatic vein (THV). Thickening and cellularity of the venular wall and the volume density of sinusoidal lumen (Vsl) in the Zone I and III of the hepatic acinus, were also evaluated. The morphometric analysis used computerized measurements. In DA, the sinusoidal dilatation (100% of cases), the sinusoidal and THV inflammation (81% and 67.7%, respectively), localized mainly in the centrilobular zone, were more pronounced than in ex-DA, in patients with PTCAH and in CONTROL (significantly differentP<0.0001). Conversely, the fibrotic reaction (perisinusoidal fibrosis−44.4% and perivenular fibrosis−61.1%) was more frequent in ex-DA. The THV inflammation in DA was replaced by a fibrotic matrix deposit in the THV wall (wall surface/internal surface=2.72±0.37 in ex-DA; 1.38±0.32 in DA; 0.87±0.14 in PTCAH and 0.45±0.03 in CONTROL-significantly differentP<0.001), associated with a perisinusoidal fibrosis, after drug withdrawal. Moreover, there was significantly decreased venular wall cellularity in ex-DA (wall surface/mesenchymal cells=949±158 in ex-DA; 622±40 in DA; 619±61 in PTCAH; 547±23 in CONTROL —P<0.001). Semiquantitative and morphometric data suggest that these vascular lesions and their reversibility may be due to the direct hepatotoxic effects of heroin. Springer-Verlag, 1990 Liver nationallicence Hepatic veins nationallicence Sinusoids nationallicence Heroin nationallicence Morphometry nationallicence de Araújo Maria Laboratoire de Pathologie Cellulaire, Institut Pasteur CNRS URA 602, Lyon, France aut Gerard Françoise Laboratoire de Pathologie Cellulaire, Institut Pasteur CNRS URA 602, Lyon, France aut Chossegros Philippe Service de Médecine Interne, Unité d'Hépatologie Hôtel Dieu, Lyon, France aut Porto Luís Laboratoire de Pathologie Cellulaire, Institut Pasteur CNRS URA 602, Lyon, France aut Barlet Pierre Service de Médecine Pénitenciaire, Centre Hospitalier Lyon-Sud, Lyon, France aut Grimaud Jean-Alexis Laboratoire de Pathologie Cellulaire, Institut Pasteur CNRS URA 602, Lyon, France aut Virchows Archiv A Springer-Verlag 417/6(1990-11-01), 497-503 0174-7398 417:6<497 1990 417 428 https://doi.org/10.1007/BF01625730 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01625730 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Araújo Maria Laboratoire de Pathologie Cellulaire, Institut Pasteur CNRS URA 602, Lyon, France aut NATIONALLICENCE 700 1- Gerard Françoise Laboratoire de Pathologie Cellulaire, Institut Pasteur CNRS URA 602, Lyon, France aut NATIONALLICENCE 700 1- Chossegros Philippe Service de Médecine Interne, Unité d'Hépatologie Hôtel Dieu, Lyon, France aut NATIONALLICENCE 700 1- Porto Luís Laboratoire de Pathologie Cellulaire, Institut Pasteur CNRS URA 602, Lyon, France aut NATIONALLICENCE 700 1- Barlet Pierre Service de Médecine Pénitenciaire, Centre Hospitalier Lyon-Sud, Lyon, France aut NATIONALLICENCE 700 1- Grimaud Jean-Alexis Laboratoire de Pathologie Cellulaire, Institut Pasteur CNRS URA 602, Lyon, France aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/6(1990-11-01), 497-503 0174-7398 417:6<497 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer