caa a22 4500 46575368X CHVBK 20180323111841.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF01625732 doi (NATIONALLICENCE)springer-10.1007/BF01625732 Ultrastructural quantitation of atubular and hypertrophic glomeruli in rats with lithium-induced chronic nephropathy [Elektronische Daten] [Niels Marcussen, Peter Ottosen, Sten Christensen] Summary: The very heterogeneous population of glomeruli in rats with lithium-induced chronic nephropathy which includes small glomeruli without connection to a proximal tubule (atubular glomeruli) and large hypertropic glomeruli with connection to a normal proximal tubule, was studied at the ultrastructural level, using stereological methods. After 8 weeks of lithium treatment followed by 8 weeks without lithium the hypertrophic glomeruli showed no changes in their relative ultrastructural composition, including normal mesangium, basement membrane-like material and peripheral basement membrane. The absolute quantities of each component were, however, increased due to the increased volume of the glomeruli. The atubular glomeruli had increased volume fractions of mesangium, peripheral basement membrane, basement membrane-like material and epithelium, whereas the absolute quantities were decreased due to the decreased volume. The thickness of the basement membrane was within normal limits in the group of hypertrophic glomeruli but increased by 31% above controls in the group of atubular glomeruli. Both groups of glomeruli in lithium-treated animals showed normal mean foot process width, but with a slightly abnormal distribution. The atubular glomeruli showed a disproportionate large decrease in peripheral filtration surface and capillary length, compared with the reduction in glomerular volume, whereas the hypertrophic glomeruli showed changes in proportion with the increased volume. Springer-Verlag, 1990 Atubular glomeruli nationallicence Chronic nephropathy nationallicence Electron microscopy nationallicence Lithium nationallicence Stereology nationallicence Marcussen Niels Aarhus Kommunehospital, University Institute of Pathology, DK-8000, Aarhus C, Denmark aut Ottosen Peter Randers Centralsygehus, Institute of Pathology, Randers, Denmark aut Christensen Sten Department of Pharmacology, University of Copenhagen, Copenhagen, Denmark aut Virchows Archiv A Springer-Verlag 417/6(1990-11-01), 513-522 0174-7398 417:6<513 1990 417 428 https://doi.org/10.1007/BF01625732 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01625732 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marcussen Niels Aarhus Kommunehospital, University Institute of Pathology, DK-8000, Aarhus C, Denmark aut NATIONALLICENCE 700 1- Ottosen Peter Randers Centralsygehus, Institute of Pathology, Randers, Denmark aut NATIONALLICENCE 700 1- Christensen Sten Department of Pharmacology, University of Copenhagen, Copenhagen, Denmark aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/6(1990-11-01), 513-522 0174-7398 417:6<513 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer