caa a22 4500 465753752 CHVBK 20180323111841.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF01600135 doi (NATIONALLICENCE)springer-10.1007/BF01600135 Pathomorphological changes in rat brain choroid plexus due to administration of the amine-curing agent, bis(4-amino-3-methylcyclohexyl)methane [Elektronische Daten] [Toshikatsu Shibata, Susumu Ohshima, Yoshihiko Shimizu, Masako Suzuki, Masahiro Ishizuka, Norihiro Sasaki, Eiki Nakayama] Summary: Repeated oral administration of an amine-curing agent for epoxy resin, bis(4-amino-3-methylcyclohexyl)methane, gave rise to severe damage in the choroid plexus of rat brain. The damaged epithelium presented varying degrees of swelling and hydropic vacuolation on light microscopy, and varying numbers of vacuoles and inclusion bodies, frequently with lamellar structure, on transmission electron microscopy. Scanning electron microscopy of the choroid plexus disclosed some irregularity in the size of epithelial cells and occasional loss of microvilli. These changes in the choroid plexus were closely correlated with the dosage of the agent administered and the period of administration. In spite of the severe changes in the choroid plexus, no neurological abnormalities were observed in the animals during the experimental period. Springer-Verlag, 1990 Bis(4-amino-3-methylcyclohexyl)methane nationallicence Choroid plexus nationallicence Inclusion body nationallicence Hydropic vacuolation nationallicence Drug-induced lipidosis nationallicence Shibata Toshikatsu Second Department of Pathology, Saitama Medical School, 38 Moro-Hongo, Moroyama-machi, Iruma-gun, 350-04, Saitama, Japan aut Ohshima Susumu Second Department of Pathology, Saitama Medical School, 38 Moro-Hongo, Moroyama-machi, Iruma-gun, 350-04, Saitama, Japan aut Shimizu Yoshihiko Second Department of Pathology, Saitama Medical School, 38 Moro-Hongo, Moroyama-machi, Iruma-gun, 350-04, Saitama, Japan aut Suzuki Masako Second Department of Pathology, Saitama Medical School, 38 Moro-Hongo, Moroyama-machi, Iruma-gun, 350-04, Saitama, Japan aut Ishizuka Masahiro Second Department of Pathology, Saitama Medical School, 38 Moro-Hongo, Moroyama-machi, Iruma-gun, 350-04, Saitama, Japan aut Sasaki Norihiro Occupational Health Service Centre, Japan Industrial Safety and Health Association, Tokyo aut Nakayama Eiki Japan Bioassay Laboratory, Japan Industrial Safety and Health Association, Kanagawa, Japan aut Virchows Archiv A Springer-Verlag 417/3(1990-05-01), 203-212 0174-7398 417:3<203 1990 417 428 https://doi.org/10.1007/BF01600135 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01600135 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shibata Toshikatsu Second Department of Pathology, Saitama Medical School, 38 Moro-Hongo, Moroyama-machi, Iruma-gun, 350-04, Saitama, Japan aut NATIONALLICENCE 700 1- Ohshima Susumu Second Department of Pathology, Saitama Medical School, 38 Moro-Hongo, Moroyama-machi, Iruma-gun, 350-04, Saitama, Japan aut NATIONALLICENCE 700 1- Shimizu Yoshihiko Second Department of Pathology, Saitama Medical School, 38 Moro-Hongo, Moroyama-machi, Iruma-gun, 350-04, Saitama, Japan aut NATIONALLICENCE 700 1- Suzuki Masako Second Department of Pathology, Saitama Medical School, 38 Moro-Hongo, Moroyama-machi, Iruma-gun, 350-04, Saitama, Japan aut NATIONALLICENCE 700 1- Ishizuka Masahiro Second Department of Pathology, Saitama Medical School, 38 Moro-Hongo, Moroyama-machi, Iruma-gun, 350-04, Saitama, Japan aut NATIONALLICENCE 700 1- Sasaki Norihiro Occupational Health Service Centre, Japan Industrial Safety and Health Association, Tokyo aut NATIONALLICENCE 700 1- Nakayama Eiki Japan Bioassay Laboratory, Japan Industrial Safety and Health Association, Kanagawa, Japan aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/3(1990-05-01), 203-212 0174-7398 417:3<203 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer