caa a22 4500 465753779 CHVBK 20180323111841.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF01600144 doi (NATIONALLICENCE)springer-10.1007/BF01600144 Calcitonin free oat-cell carcinoma of the thyroid gland [Elektronische Daten] [V. Eusebi, S. Damiani, C. Riva, R. Lloyd, C. Capella] Summary: Two cases of primary oat-cell carcinoma of thyroid, in a 63-year-old woman and a 73-year-old man, are described. Case 1 was a compound tumour with the oat-cell component merging with a papillary component. Both tumours, in addition to histological features consistent with oat-cell carcinoma, showed immunohistochemical positivity with anti-chromagranin A and anti-synaptophysin antisera. Negative results were obtained when anti-calcitonin and anti-thyroglobulin antisera were employed. Using in situ hybridization, chromogranin A and B messenger RNAs were localized with biotinylated oligonucleotide probes. In contrast, with in situ hybridization, no localization for calcitonin messenger RNA was seen using radioactive and biotinylated probes. It is concluded that these calcitonin-free, small-cell carcinomas should be considered separately from medullary thyroid carcinomas and be regarded as a distinct entity, probably the thyroid equivalent of oat-cell carcinomas of the lung. Springer-Verlag, 1990 Thyroid nationallicence Oat-cell carcinoma nationallicence Calcitonin-free small-cell carcinoma nationallicence Eusebi V. Istituto di Anatomia e Istologia Patologica, Universit/'a di Bologna, Sede distaccata Ospedale Bellaria, via Altura 3, I-40139, Bologna, Italy aut Damiani S. Istituto di Anatomia e Istologia Patologica, Universit/'a di Bologna, Sede distaccata Ospedale Bellaria, via Altura 3, I-40139, Bologna, Italy aut Riva C. Department of Human Pathology, Pavia University, Varese, Italy aut Lloyd R. Department of Pathology, University of Michigan Hospital, Ann Arbor, Michigan, USA aut Capella C. Department of Human Pathology, Pavia University, Varese, Italy aut Virchows Archiv A Springer-Verlag 417/3(1990-05-01), 267-271 0174-7398 417:3<267 1990 417 428 https://doi.org/10.1007/BF01600144 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01600144 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Eusebi V. Istituto di Anatomia e Istologia Patologica, Universit/'a di Bologna, Sede distaccata Ospedale Bellaria, via Altura 3, I-40139, Bologna, Italy aut NATIONALLICENCE 700 1- Damiani S. Istituto di Anatomia e Istologia Patologica, Universit/'a di Bologna, Sede distaccata Ospedale Bellaria, via Altura 3, I-40139, Bologna, Italy aut NATIONALLICENCE 700 1- Riva C. Department of Human Pathology, Pavia University, Varese, Italy aut NATIONALLICENCE 700 1- Lloyd R. Department of Pathology, University of Michigan Hospital, Ann Arbor, Michigan, USA aut NATIONALLICENCE 700 1- Capella C. Department of Human Pathology, Pavia University, Varese, Italy aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/3(1990-05-01), 267-271 0174-7398 417:3<267 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer