caa a22 4500 465753795 CHVBK 20180323111841.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF01600137 doi (NATIONALLICENCE)springer-10.1007/BF01600137 An electron microscopic study of glomerular lesions in hereditary nephrotic mice (ICGN strain) [Elektronische Daten] [Atsuo Ogura, Toshihiko Asano, Junichiro Matsuda, Minako Koura, Masaro Nakagawa, Hiroshi Kawaguchi, Yutaka Yamaguchi] Summary: Glomerular lesions in hereditary nephrotic mice (ICGN strain) were investigated by electron microscopy. The glomeruli of unaffected animals, which appeared normal by light microscopy, had developed an ultrastructural change in the glomerular capillary basement membrane (GCBM). There was a partial thickening of the GCBM with bilaminar splitting of the lamina densa and an electron-dense fibrillar material exhibiting cross-striations. In affected animals, light microscopy revealed a marked thickening of GCBM and an increase of mesangial matrix without cellular proliferaton. By electron microscopy, multilaminar splitting of the lamina densa in the thickened GCBMs and fusion of the epithelial foot processes were observed. In some severely affected animals, immune complex deposition was found in GCBM, but little if any was observed in other animals. In the end, the glomeruli were globally sclerosed. Our findings suggest that initial structural abnormalities in GCBM may play an important role in the onset and development of the disease, though subsequent events such as immune complex deposition would modify the disease. Springer-Verlag, 1990 Mouse nationallicence Nephrotic syndrome nationallicence Hereditary nephritis nationallicence Electron microscopy nationallicence Ogura Atsuo Department of Veterminary Science, National Institute of Health, 10-35, 2-Chome, Kamiosaki, Shinagawa-ku, 141, Tokyo, Japan aut Asano Toshihiko Department of Veterminary Science, National Institute of Health, 10-35, 2-Chome, Kamiosaki, Shinagawa-ku, 141, Tokyo, Japan aut Matsuda Junichiro Department of Veterminary Science, National Institute of Health, 10-35, 2-Chome, Kamiosaki, Shinagawa-ku, 141, Tokyo, Japan aut Koura Minako Department of Veterminary Science, National Institute of Health, 10-35, 2-Chome, Kamiosaki, Shinagawa-ku, 141, Tokyo, Japan aut Nakagawa Masaro Department of Veterminary Science, National Institute of Health, 10-35, 2-Chome, Kamiosaki, Shinagawa-ku, 141, Tokyo, Japan aut Kawaguchi Hiroshi Department of Pediatric Nephrology, Kidney Center, Tokyo Women's Medical College, Tokyo, Japan aut Yamaguchi Yutaka Department of Pathology, The Jikei University of Medicine, Tokyo, Japan aut Virchows Archiv A Springer-Verlag 417/3(1990-05-01), 223-228 0174-7398 417:3<223 1990 417 428 https://doi.org/10.1007/BF01600137 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01600137 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ogura Atsuo Department of Veterminary Science, National Institute of Health, 10-35, 2-Chome, Kamiosaki, Shinagawa-ku, 141, Tokyo, Japan aut NATIONALLICENCE 700 1- Asano Toshihiko Department of Veterminary Science, National Institute of Health, 10-35, 2-Chome, Kamiosaki, Shinagawa-ku, 141, Tokyo, Japan aut NATIONALLICENCE 700 1- Matsuda Junichiro Department of Veterminary Science, National Institute of Health, 10-35, 2-Chome, Kamiosaki, Shinagawa-ku, 141, Tokyo, Japan aut NATIONALLICENCE 700 1- Koura Minako Department of Veterminary Science, National Institute of Health, 10-35, 2-Chome, Kamiosaki, Shinagawa-ku, 141, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakagawa Masaro Department of Veterminary Science, National Institute of Health, 10-35, 2-Chome, Kamiosaki, Shinagawa-ku, 141, Tokyo, Japan aut NATIONALLICENCE 700 1- Kawaguchi Hiroshi Department of Pediatric Nephrology, Kidney Center, Tokyo Women's Medical College, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamaguchi Yutaka Department of Pathology, The Jikei University of Medicine, Tokyo, Japan aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/3(1990-05-01), 223-228 0174-7398 417:3<223 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer