caa a22 4500 465753825 CHVBK 20180323111841.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF01600145 doi (NATIONALLICENCE)springer-10.1007/BF01600145 Lipid-rich cell thyroid adenoma: histopathology with comparative lipid analysis [Elektronische Daten] [K. Tóth, I. Péter, T. Kremmer, J. Sugár] Summary: A second case of the unique lipid-rich cell thyroid adenoma is described complemented by detailed lipid analysis. New observations were made. The cytoplasm of the tumour cells contained scattered, aggregated sudanophil crystals; under polarized light the frozen, unstained sections exhibited numerous birefringent lipid crystals; electron microscopy provided further evidence that the clear cell appearance was due to intracellular lipid droplets with scanty glycogen particles. Comparative lipid analysis by thin layer chromatography and high-pressure liquid chromatography (HPLC) revealed quantitative and qualitative differences in lipid composition of tumour cells when compared with goitre cells from normal thyroid gland and subcutane fat. Qualitative differences in triglyceride composition (by HPLC) between tumour cells and subcutaneous fat indicated that the fat accumulation in the follicle cells was not a result of simple storage, but an expression of altered intracellular lipid metabolism. Springer-Verlag, 1990 Thyroid nationallicence Lipid-rich cell adenoma nationallicence Crystals nationallicence Lipid analysis nationallicence Subcutaneous fat nationallicence Tóth K. Department of Human and Experimental Tumorpathology, National Oncological Institute, Ráth György street 7-9, 1122, Budapest, Hungary aut Péter I. Department of Human and Experimental Tumorpathology, National Oncological Institute, Ráth György street 7-9, 1122, Budapest, Hungary aut Kremmer T. Department of Biochemistry, National Oncological Institute, Ráth György street 7-9, 1122, Budapest, Hungary aut Sugár J. Department of Human and Experimental Tumorpathology, National Oncological Institute, Ráth György street 7-9, 1122, Budapest, Hungary aut Virchows Archiv A Springer-Verlag 417/3(1990-05-01), 273-276 0174-7398 417:3<273 1990 417 428 https://doi.org/10.1007/BF01600145 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01600145 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tóth K. Department of Human and Experimental Tumorpathology, National Oncological Institute, Ráth György street 7-9, 1122, Budapest, Hungary aut NATIONALLICENCE 700 1- Péter I. Department of Human and Experimental Tumorpathology, National Oncological Institute, Ráth György street 7-9, 1122, Budapest, Hungary aut NATIONALLICENCE 700 1- Kremmer T. Department of Biochemistry, National Oncological Institute, Ráth György street 7-9, 1122, Budapest, Hungary aut NATIONALLICENCE 700 1- Sugár J. Department of Human and Experimental Tumorpathology, National Oncological Institute, Ráth György street 7-9, 1122, Budapest, Hungary aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/3(1990-05-01), 273-276 0174-7398 417:3<273 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer