caa a22 4500 465753884 CHVBK 20180323111841.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF01605787 doi (NATIONALLICENCE)springer-10.1007/BF01605787 Immunohistological characteristics of the infiltrating lymphoid cells and expression of HLA class I and II antigens in nasopharyngeal carcinoma [Elektronische Daten] [F. Lai, Paul Cheng, S. Tsao, K. Lai] Summary: The immunohistological characteristics of infiltrating lymphoid cells and the expression of human leucocyte antigens class I and II (HLA-ABC and HLA-DR, respectively) were studied in 50 pre-treatment nasopharyngeal carcinomas. The majority of lymphoid cells were activated lymphocytes expressing thymocyte OKT10 marker. CD4+ cells (T-helper/inducer) out-numbered CD8+ cells (T-suppressor/cytotoxic) by at least two-to four-fold. CD22+cells (pan-B lymphocytes) were scanty in the peri-tumoral areas and were absent in 29 out of 50 biopsies. A moderate number of cells expressing CD15 (monocytes/macrophages) were also detected. CD16+ cells (natural killer cells) were found to be sparse or absent. Expression of HLA class I and II antigens on the tumor cells in 35 biopsies was variable. HLA-ABC staining was intense in 6, reduced in 13 and partially lost in 16, whereas staining of HLADR was intense in 7, reduced in 11 and partially lost in 17. Full expression of both antigens was demonstrable in only 2 biopsy samples. The expression of HLA antigens in the tumour had no relationship to the type or degree of lymphocytic infiltration or staging of the tumour. Springer-Verlag, 1990 Nasopharyngeal carcinoma nationallicence HLA antigens nationallicence Lymphocyte subsets nationallicence Lai F. Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong aut Cheng Paul Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong aut Tsao S. Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong aut Lai K. Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong aut Virchows Archiv A Springer-Verlag 417/4(1990-07-01), 347-352 0174-7398 417:4<347 1990 417 428 https://doi.org/10.1007/BF01605787 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605787 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lai F. Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong aut NATIONALLICENCE 700 1- Cheng Paul Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong aut NATIONALLICENCE 700 1- Tsao S. Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong aut NATIONALLICENCE 700 1- Lai K. Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/4(1990-07-01), 347-352 0174-7398 417:4<347 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer