caa a22 4500 465753922 CHVBK 20180323111841.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF01605781 doi (NATIONALLICENCE)springer-10.1007/BF01605781 Histology of gastric biopsies from peptic ulcer patients before and after short-term treatment with omeprazole or H2-receptor antagonists [Elektronische Daten] [Herbert Helander, Magnus Simonsson, Frank Sundler, Kerstin Rutgersson, Kerstin Helander, Sven Eriksson] Summary: Sixty patients with duodenal or prepyloric ulcers were given omeprazole (30 or 40 mg o.m.; average period of treatment: 2.9 weeks) or histamine H2-receptor antagonists (cimetidine 400 mg b.i.d. or ranitidine 150 mg b.i.d.; average period of treatment: 3.5 weeks) for a single period ranging between 2 and 6 weeks. At the end of the treatment period fasting plasma gastrin levels were moderately increased in both groups in comparison with the pretreatment values. Endoscopic biopsies were taken from the oxyntic mucosa at the beginning and at the end of the treatment period. Light microscopy of the biopsies was aimed particularly at determining the number of endocrine cells. In addition, the mucosal thickness and the volume densities of the parietal cells, the lamina propria and the gland lumina were measured. There were no significant differences in the endocrine or parietal cell populations, between biopsies taken from the patients before and after treatment with omeprazole or histamine H2-receptor antagonists. The mucosal thickness and the densities of the lamina propria and of the gland lumina remained unaffected by the treatment. Springer-Verlag, 1990 Gastric mucosa nationallicence Gastrin nationallicence H2 receptor antagonists nationallicence Morphometry nationallicence Omeprazole nationallicence Helander Herbert AB Hässle, 431 83, Mölndal, Sweden aut Simonsson Magnus Department of Medical Cell Research, University of Lund, Lund, Sweden aut Sundler Frank Department of Medical Cell Research, University of Lund, Lund, Sweden aut Rutgersson Kerstin AB Hässle, 431 83, Mölndal, Sweden aut Helander Kerstin AB Hässle, 431 83, Mölndal, Sweden aut Eriksson Sven AB Hässle, 431 83, Mölndal, Sweden aut Virchows Archiv A Springer-Verlag 417/4(1990-07-01), 305-309 0174-7398 417:4<305 1990 417 428 https://doi.org/10.1007/BF01605781 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605781 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Helander Herbert AB Hässle, 431 83, Mölndal, Sweden aut NATIONALLICENCE 700 1- Simonsson Magnus Department of Medical Cell Research, University of Lund, Lund, Sweden aut NATIONALLICENCE 700 1- Sundler Frank Department of Medical Cell Research, University of Lund, Lund, Sweden aut NATIONALLICENCE 700 1- Rutgersson Kerstin AB Hässle, 431 83, Mölndal, Sweden aut NATIONALLICENCE 700 1- Helander Kerstin AB Hässle, 431 83, Mölndal, Sweden aut NATIONALLICENCE 700 1- Eriksson Sven AB Hässle, 431 83, Mölndal, Sweden aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/4(1990-07-01), 305-309 0174-7398 417:4<305 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer