caa a22 4500 465753949 CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF01605780 doi (NATIONALLICENCE)springer-10.1007/BF01605780 Decay-accelerating factor in the cardiomyocytes of normal individuals and patients with myocardial infarction [Elektronische Daten] [Arthur Zimmermann, Heinz Gerber, Victor Nussenzweig, Henri Isliker] Summary: The presence of decay-accelerating factor (DAF) was clearly demonstrated on the surface of normal cardiomyocytes. In patients who had died of myocardial infarction (MI) cardiomyocytes displayed different appearances: outside the ischaemically damaged region the myocytes showed no significant variations in DAF expression when compared with controls without MI. Within myocardial zones damaged by ischaemia, however, apparently normal myocytes showed large gaps in surface staining of DAF or formed clusters which were entirely devoid of reactivity with anti-DAF antibodies. The number of DAF-deficient myocytes increased with the extent of necrosis and also with the number of days between onset of MI and death. Even though injury to myocytes is to a large extent related to anoxia and to the presence of free oxygen radicals, the complement system also appears to be involved; DAF may have protective functions against complement-mediated injury. We speculate that phospholipase may be involved in the removal of DAF from the cardiomyocyte surface. Springer-Verlag, 1990 Decay-accelerating factor nationallicence Cardiomyocytes nationallicence Myocardial infarction nationallicence Zimmermann Arthur Institute of Pathology, University of Bern, Bern, Switzerland aut Gerber Heinz Institute of Pathology, University of Bern, Bern, Switzerland aut Nussenzweig Victor Department of Pathology, New York University School of Medicine, New York, USA aut Isliker Henri Institute of Biochemistry, University of Lausanne, Lausanne, Switzerland aut Virchows Archiv A Springer-Verlag 417/4(1990-07-01), 299-304 0174-7398 417:4<299 1990 417 428 https://doi.org/10.1007/BF01605780 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605780 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zimmermann Arthur Institute of Pathology, University of Bern, Bern, Switzerland aut NATIONALLICENCE 700 1- Gerber Heinz Institute of Pathology, University of Bern, Bern, Switzerland aut NATIONALLICENCE 700 1- Nussenzweig Victor Department of Pathology, New York University School of Medicine, New York, USA aut NATIONALLICENCE 700 1- Isliker Henri Institute of Biochemistry, University of Lausanne, Lausanne, Switzerland aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/4(1990-07-01), 299-304 0174-7398 417:4<299 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer