caa a22 4500 465753973 CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF01605785 doi (NATIONALLICENCE)springer-10.1007/BF01605785 Insulin therapy prevents spontaneous recovery from streptozotocin-induced diabetes in Syrian hamsters [Elektronische Daten] An autoradiographic and immunohistochemical study [Parviz Pour, William Duckworth, Kim Carlson, Kathy Kazakoff] Summary: Streptozotocin (Sz) given as a single dose of 50 mg/kg body wt. caused severe diabetes in Syrian hamsters. However, the level of blood glucose decreased gradually after 21 days post-Sz and reached the near normal level at 70 days in 90% of hamsters. The recovery from diabetes was associated with the regeneration of theβ-cells of islets and a reduction in the initially increased number ofα- andδ-cells. Daily treatment of diabetic hamsters with insulin was associated with the persistence of severe diabetes, lack of or minimal tendency forβ-cell regeneration and sustained hyperplasia ofα- andδ-cells in 90% of hamsters. Insulin also inhibited DNA synthesis (as measured by incorporation of tritiated thymidine), in ductal, ductular and acinar cells in Sz-pretreated hamsters but not in normoglycemic control hamsters treated with insulin alone. The results demonstrate a deleterious effect of exogenous insulin in the course of Sz-induced diabetes in hamsters. Springer-Verlag, 1990 Streptozotocin nationallicence Diabetes nationallicence Syrian hamsters nationallicence Autoradiography nationallicence Immunohistochemistry nationallicence Pour Parviz The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S, 42nd St, 68198, Omaha, NE, USA aut Duckworth William Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA aut Carlson Kim The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S, 42nd St, 68198, Omaha, NE, USA aut Kazakoff Kathy The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S, 42nd St, 68198, Omaha, NE, USA aut Virchows Archiv A Springer-Verlag 417/4(1990-07-01), 333-341 0174-7398 417:4<333 1990 417 428 https://doi.org/10.1007/BF01605785 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605785 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pour Parviz The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S, 42nd St, 68198, Omaha, NE, USA aut NATIONALLICENCE 700 1- Duckworth William Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA aut NATIONALLICENCE 700 1- Carlson Kim The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S, 42nd St, 68198, Omaha, NE, USA aut NATIONALLICENCE 700 1- Kazakoff Kathy The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 600 S, 42nd St, 68198, Omaha, NE, USA aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/4(1990-07-01), 333-341 0174-7398 417:4<333 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer