caa a22 4500 46575399X CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF01605783 doi (NATIONALLICENCE)springer-10.1007/BF01605783 Morphometric analysis of arteriolar diameters in experimental nephropathies: Application of microvascular casts [Elektronische Daten] [Kenjiro Kimura, Akihiro Tojo, Shinichiro Nanba, Hiroaki Matsuoka, Tsuneaki Sugimoto] Summary: Renal arteriolar diameters were measured, using microvascular resin casts, in two hyperfiltration models of rats: the remnants kidney of subtotal nephrectomy (NX) and streptozotocin-induced diabetic kidney (DM). In the NX, the blood pressure was elevated, urinary protein excretion was markedly increased and glomeruli were severely damaged. In the DM, although the blood pressure remained normal, urinary protein excretion was significantly increased and glomeruli were damaged but to a lesser extent than in the NX group. In the NX group, the afferent arteriole was dilated and the efferent arteriole was constricted. In the DM group, the afferent arteriole was dilated, while the efferent arteriole remained unchanged. The results showed that afferent arteriolar dilatation was seen in both the NX and DM groups, possibly leading to the glomerular damage. In the NX group, the systemic high blood pressure and efferent arteriolar constriction augmented glomerular damage significantly. Springer-Verlag, 1990 Vascular cast nationallicence Arteriole nationallicence Kidney nationallicence Subtotal nephrectomy nationallicence Diabetic nephropathy nationallicence Kimura Kenjiro The Second Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, 113, Tokyo, Japan aut Tojo Akihiro The Second Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, 113, Tokyo, Japan aut Nanba Shinichiro The Second Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, 113, Tokyo, Japan aut Matsuoka Hiroaki The Second Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, 113, Tokyo, Japan aut Sugimoto Tsuneaki The Second Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, 113, Tokyo, Japan aut Virchows Archiv A Springer-Verlag 417/4(1990-07-01), 319-323 0174-7398 417:4<319 1990 417 428 https://doi.org/10.1007/BF01605783 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01605783 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kimura Kenjiro The Second Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Tojo Akihiro The Second Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Nanba Shinichiro The Second Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Matsuoka Hiroaki The Second Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Sugimoto Tsuneaki The Second Department of Internal Medicine, Faculty of Medicine, The University of Tokyo, 113, Tokyo, Japan aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/4(1990-07-01), 319-323 0174-7398 417:4<319 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer