caa a22 4500 465754074 CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF01606032 doi (NATIONALLICENCE)springer-10.1007/BF01606032 Ultrastructure of invasion in different tissue types by lewis lung tumour variants [Elektronische Daten] [S. Paku, J. Timár, K. Lapis] Summary: Ultrastructural studies on the interactions of low and highly metastatic 3LL tumour lines with the basement membranes (BMs) of capillaries, veins, muscles, nerves and adipose tissue were performed by injecting tumour cells into the foot pad of mice. Haematogenous dissemination is the principle route of metastasis formation. Cells from the highly metastatic line were able to penetrate the blood vessels more efficiently than those from the low metastatic line. This difference was mainly due to a more pronounced diapedesis-like activity of the 3LL-HH cells, and partly to the altered intratumour vessel architecture in the highly metastatic tumour line. There was no difference between the two lines in the ultrastructure and frequency of invasion of nerves and adipose tissue BMs. However, in the highly metastatic line an extremely efficient penetration of muscle cell BM was observed. These results provide further evidence that the interaction of tumour cells with the BMs of different tissue types is one of the main determinants in local and distant dissemination. Springer-Verlag, 1990 Paku S. First Institute of Pathology and Experimental Cancer Research Semmelweis Medical University, üllöi ut 26, H-1085, Budapest, Hungary aut Timár J. First Institute of Pathology and Experimental Cancer Research Semmelweis Medical University, üllöi ut 26, H-1085, Budapest, Hungary aut Lapis K. First Institute of Pathology and Experimental Cancer Research Semmelweis Medical University, üllöi ut 26, H-1085, Budapest, Hungary aut Virchows Archiv A Springer-Verlag 417/5(1990-09-01), 435-442 0174-7398 417:5<435 1990 417 428 https://doi.org/10.1007/BF01606032 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01606032 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paku S. First Institute of Pathology and Experimental Cancer Research Semmelweis Medical University, üllöi ut 26, H-1085, Budapest, Hungary aut NATIONALLICENCE 700 1- Timár J. First Institute of Pathology and Experimental Cancer Research Semmelweis Medical University, üllöi ut 26, H-1085, Budapest, Hungary aut NATIONALLICENCE 700 1- Lapis K. First Institute of Pathology and Experimental Cancer Research Semmelweis Medical University, üllöi ut 26, H-1085, Budapest, Hungary aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/5(1990-09-01), 435-442 0174-7398 417:5<435 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer