caa a22 4500 465754082 CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF01606030 doi (NATIONALLICENCE)springer-10.1007/BF01606030 Topography-related expression of individual cytokeratins in normal and pathological (non-neoplastic and neoplastic) human oral mucosa [Elektronische Daten] [Marcella Cintorino, Roberto Petracca, Carla Vindigni, Sergio Tripodi, Paolo Leoncini] Summary: Recently, regional changes of cytokeratin patterns in human normal non-keratinized or keratinized oral mucosa have been demonstrated and the expression of individual cytokeratin polypeptides in lesions of oral mucosa has been compared with that of normal tissues. In particular, the presence of cytokeratin 19 in the suprabasal cell layers of oral epithelia has been shown to be strongly correlated with premalignancy. In the present study, we describe the results of an immunohistochemical investigation performed using a monoclonal antibody specific for cytokeratin 1 on normal oral mucosa and benign or malignant oral lesions. We show the different distribution of this polypeptide in non-neoplastic lesions from different sites of oral mucosa and describe the presence of cytokeratin 19. Our results are in agreement with the data obtained previously. In the malignant cases we demonstrate that the distribution of the two cytokeratins is characterized by complementary patterns. Springer-Verlag, 1990 Cytokeratins nationallicence Oral leukoplakia nationallicence Oral carcinoma nationallicence Cintorino Marcella Department of Pathology, University of Siena, I-53100, Siena, Italy aut Petracca Roberto Sclavo Research Center, Via Fiorentina 1, I-53100, Siena, Italy aut Vindigni Carla Department of Pathology, University of Siena, I-53100, Siena, Italy aut Tripodi Sergio Department of Pathology, University of Siena, I-53100, Siena, Italy aut Leoncini Paolo Sclavo Research Center, Via Fiorentina 1, I-53100, Siena, Italy aut Virchows Archiv A Springer-Verlag 417/5(1990-09-01), 419-426 0174-7398 417:5<419 1990 417 428 https://doi.org/10.1007/BF01606030 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01606030 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cintorino Marcella Department of Pathology, University of Siena, I-53100, Siena, Italy aut NATIONALLICENCE 700 1- Petracca Roberto Sclavo Research Center, Via Fiorentina 1, I-53100, Siena, Italy aut NATIONALLICENCE 700 1- Vindigni Carla Department of Pathology, University of Siena, I-53100, Siena, Italy aut NATIONALLICENCE 700 1- Tripodi Sergio Department of Pathology, University of Siena, I-53100, Siena, Italy aut NATIONALLICENCE 700 1- Leoncini Paolo Sclavo Research Center, Via Fiorentina 1, I-53100, Siena, Italy aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/5(1990-09-01), 419-426 0174-7398 417:5<419 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer