caa a22 4500 465754090 CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF01606025 doi (NATIONALLICENCE)springer-10.1007/BF01606025 Immunohistochemical localization of oestrogen receptors and progesterone receptors in the human ovary throughout the menstrual cycle [Elektronische Daten] [Toshiko Iwai, Yoshihiko Nanbu, Masazumi Iwai, Shunzou Taii, Shingo Fujii, Takahide Mori] Summary: Immunohistochemistry was used to determine the distribution of oestrogen receptors (ER) and progesterone receptors (PR) in the human ovary during folliculogenesis. Primordial and preantral follicles did not contain ER or PR. The granulosa cells of antral follicles had ER, but negligible PR, before the LH surge. In contrast, at the time of LH surge, these cells of the dominant follicle contained PR, but not ER. On the other hand, granulosa cells of the non-dominant follicles had ER, but not PR. After ovulation, the PR persisted in the luteinized granulosa cells and in the corpus luteum during early pregnancy. The theca interna and surrounding stromal cells were ER-negative and PR-positive throughout the menstrual cycle. Thus, the results show that ER and PR are not expressed simultaneously in the granulosa cells, the thecal cells, or the stromal cells during folliculogenesis. Mechanisms controlling the expression of steroid receptors during the normal menstrual cycle and in early pregnancy are discussed. Springer-Verlag, 1990 Oestrogen receptor nationallicence Progesterone receptor nationallicence Human ovary nationallicence Immunohistochemistry nationallicence Iwai Toshiko Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyoku, 606, Kyoto, Japan aut Nanbu Yoshihiko Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyoku, 606, Kyoto, Japan aut Iwai Masazumi Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyoku, 606, Kyoto, Japan aut Taii Shunzou Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyoku, 606, Kyoto, Japan aut Fujii Shingo Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyoku, 606, Kyoto, Japan aut Mori Takahide Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyoku, 606, Kyoto, Japan aut Virchows Archiv A Springer-Verlag 417/5(1990-09-01), 369-375 0174-7398 417:5<369 1990 417 428 https://doi.org/10.1007/BF01606025 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01606025 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iwai Toshiko Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyoku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Nanbu Yoshihiko Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyoku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Iwai Masazumi Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyoku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Taii Shunzou Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyoku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Fujii Shingo Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyoku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Mori Takahide Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyoku, 606, Kyoto, Japan aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/5(1990-09-01), 369-375 0174-7398 417:5<369 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer