caa a22 4500 465754112 CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF01606029 doi (NATIONALLICENCE)springer-10.1007/BF01606029 Comparative histogenesis and morphogenesis of mucoepidermoid carcinoma and pleomorphic adenoma [Elektronische Daten] An ultrastructural study [Irving Dardick, M. Gliniecki, J. Heathcote, Aileen Burford-Mason] Summary: Current classifications of salivary gland tumors separate mucoepidermoid carcinoma from other neoplasms on the basis of a number of histological features, in particular the lack of participation of neoplastic myoepithelial cells. However, ultrastructural examination of low- and intermediate-grade mucoepidermoid carcinomas and pleomorphic adenomas reveals many common organizational and cellular features. Of prime importance is the relationship of intermediate cells to the luminal cells in mucoepidermoid carcinomas, which is remarkably similar to that seen between modified myoepithelial cells and luminal cells in pleomorphic adenomas. The results suggest that intermediate cells of mucoepidermoid carcinoma are the counterpart of the modified myoepithelial cells of pleomorphic adenoma. The generally accepted hypothesis that the former tumor develops from an excretory duct reserve cell, while the latter originates from an intercalated duct stem cell does not seem to be valid; pleomorphic adenoma and mucoepidermoid carcinoma appear to be closely related morphologically. Springer-Verlag, 1990 Salivary gland nationallicence Neoplasm nationallicence Mucoepidermoid carcinoma nationallicence Electron microscopy nationallicence Histogenesis nationallicence Dardick Irving Department of Pathology, University of Toronto, Banting Institute, Toronto, Ontario, Canada aut Gliniecki M. Department of Pathology, University of Toronto, Banting Institute, Toronto, Ontario, Canada aut Heathcote J. Department of Pathology, University of Toronto, Banting Institute, Toronto, Ontario, Canada aut Burford-Mason Aileen Department of Pathology, University of Toronto, Banting Institute, Toronto, Ontario, Canada aut Virchows Archiv A Springer-Verlag 417/5(1990-09-01), 405-417 0174-7398 417:5<405 1990 417 428 https://doi.org/10.1007/BF01606029 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01606029 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dardick Irving Department of Pathology, University of Toronto, Banting Institute, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Gliniecki M. Department of Pathology, University of Toronto, Banting Institute, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Heathcote J. Department of Pathology, University of Toronto, Banting Institute, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Burford-Mason Aileen Department of Pathology, University of Toronto, Banting Institute, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/5(1990-09-01), 405-417 0174-7398 417:5<405 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer