caa a22 4500 465754120 CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02190527 doi (NATIONALLICENCE)springer-10.1007/BF02190527 Morphological detection and quantification of lipoprotein(a) deposition in atheromatous lesions of human aorta and coronary arteries [Elektronische Daten] [Axel Niendorf, Matthias Rath, Katrin Wolf, Susanne Peters, Hartmut Arps, Ulrike Beisiegel, Manfred Dietel] Summary: Lipoprotein(a), as an atherogenic particle, represents an independent risk factor for coronary heart disease. In the present study the morphological distribution of apoprotein (a) and apoprotein B within the arterial wall is described. Apoprotein B, a constituent of very low-density lipoprotein, low-density lipoprotein and lipoprotein(a) has previously been demonstrated in atheromatous lesions. Lipoprotein(a) possesses an additional protein, designated apoprotein (a). Autopsy material (n=74) from the left coronary artery and from the thoracic aorta has been examined by means of immunohistochemistry and both apoprotein (a) and apoprotein B were detected, primarily associated with the extracellular matrix and accumulating in lesions in the arterial wall. The staining pattern for both antigens was almost always found to be congruent, suggesting that the detection of (a)-antigen has to be attributed at least in part to the presence of lipoprotein(a). It is concluded that both low-density lipoprotein and lipoprotein(a) have an important role in the pathogenesis of atherosclerosis. Springer-Verlag, 1990 Arteriosclerosis nationallicence Lipoprotein(a) nationallicence Apoprotein (a) nationallicence Immunohistochemistry nationallicence Niendorf Axel Institut für Pathologie, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut Rath Matthias Medizinische Kern- und Poliklinik Universitäts-Krankenhaus Eppendorf, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut Wolf Katrin Institut für Pathologie, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut Peters Susanne Institut für Pathologie, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut Arps Hartmut Institut für Pathologie, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut Beisiegel Ulrike Medizinische Kern- und Poliklinik Universitäts-Krankenhaus Eppendorf, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut Dietel Manfred Institut für Pathologie, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 105-111 0174-7398 417:2<105 1990 417 428 https://doi.org/10.1007/BF02190527 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02190527 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Niendorf Axel Institut für Pathologie, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut NATIONALLICENCE 700 1- Rath Matthias Medizinische Kern- und Poliklinik Universitäts-Krankenhaus Eppendorf, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut NATIONALLICENCE 700 1- Wolf Katrin Institut für Pathologie, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut NATIONALLICENCE 700 1- Peters Susanne Institut für Pathologie, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut NATIONALLICENCE 700 1- Arps Hartmut Institut für Pathologie, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut NATIONALLICENCE 700 1- Beisiegel Ulrike Medizinische Kern- und Poliklinik Universitäts-Krankenhaus Eppendorf, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut NATIONALLICENCE 700 1- Dietel Manfred Institut für Pathologie, Universität Hamburg, Martinistrasse 52, D-2000, Hamburg 20, Germany aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 105-111 0174-7398 417:2<105 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 465754120 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer