caa a22 4500 465754147 CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02190535 doi (NATIONALLICENCE)springer-10.1007/BF02190535 Steroid receptors and proliferative activity in non-neoplastic and neoplastic endometria [Elektronische Daten] [H. Pickartz, R. Beckmann, B. Fleige, W. Düe, J. Gerdes, H. Stein] Summary: In the glands of cyclic endometria, proliferative activity (PA), as revealed by expression of the Ki-67 antigen, is highest in the proliferative phase (P) and early secretory phase (S1). The PA decreases in the middle secretory phase (S2). In the stroma the PA is low during the whole cycle. In P and S1, the oestrogen receptor (ER) and the progesterone receptor (PR) are strongly expressed in glands and stroma. The number of positive cells and the staining intensity decreases in S2, particularly in the glands. In atrophic endometria, fibro-glandular polyps and in endometria with arrested secretion the PA is low in both glands and stroma. ER and PR can be detected in glands and stroma. The PA in atypical hyperplasias is only slightly higher than in cyclic endometria and endometria with simple hyperplasia. The ER and PR levels are comaparable to those in proliferative endometria. The PA of endometrial adenocarcinomas is positively and the ER and PR negatively correlated with the degree of de-differentiation. No ER-negative carcinoma displays the PR. Immunohistologically, nonneoplastic receptor positive tissue can be seen in many ER- and PR-negative carcinomas. These structures may falsify the biochemical receptor analysis. Springer-Verlag, 1990 Endometrium nationallicence Neoplastic/non-neoplastic nationallicence Proliferative activity nationallicence Steroid hormone receptor expression nationallicence Immunohistology nationallicence Pickartz H. Institutes of Pathology, Krankenhaus Spandau, Lynarstrasse 12, D-1000, Berlin 20 aut Beckmann R. Institutes of Pathology, Universitätsklinikum Steglitz, Free University, Germany aut Fleige B. Institutes of Pathology, Universitätsklinikum Steglitz, Free University, Germany aut Düe W. Institutes of Pathology, Universitätsklinikum Steglitz, Free University, Germany aut Gerdes J. Institutes of Pathology, Universitätsklinikum Steglitz, Free University, Germany aut Stein H. Institutes of Pathology, Universitätsklinikum Steglitz, Free University, Germany aut Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 163-171 0174-7398 417:2<163 1990 417 428 https://doi.org/10.1007/BF02190535 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02190535 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pickartz H. Institutes of Pathology, Krankenhaus Spandau, Lynarstrasse 12, D-1000, Berlin 20 aut NATIONALLICENCE 700 1- Beckmann R. Institutes of Pathology, Universitätsklinikum Steglitz, Free University, Germany aut NATIONALLICENCE 700 1- Fleige B. Institutes of Pathology, Universitätsklinikum Steglitz, Free University, Germany aut NATIONALLICENCE 700 1- Düe W. Institutes of Pathology, Universitätsklinikum Steglitz, Free University, Germany aut NATIONALLICENCE 700 1- Gerdes J. Institutes of Pathology, Universitätsklinikum Steglitz, Free University, Germany aut NATIONALLICENCE 700 1- Stein H. Institutes of Pathology, Universitätsklinikum Steglitz, Free University, Germany aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 163-171 0174-7398 417:2<163 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer