caa a22 4500 465754155 CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02190531 doi (NATIONALLICENCE)springer-10.1007/BF02190531 Melanocytes and melanosis of the oesophagus in Japanese subjects — analysis of factors effecting their increase [Elektronische Daten] [Kenichi Ohashi, Yo Kato, Jun Kanno, Tsutomu Kasuga] Summary: Normal oesophagus specimens taken from 65 autopsy cases and surgical specimens from 127 oesophageal carcinoma cases were examined histopathologically to determine melanocyte incidence and distribution. Melanocytes were found in the epithelio-stromal junction in 7.7% of normal oesophagus specimens examined at autopsy, and in 29.9% of surgical cases with oesophageal carcinoma. Positive specimens in the latter groups, especially from pre-operatively irradiated individuals, showed a more remarkable increase of melanocytes than was evident in any of the normal oesophageal samples. There were no significant differences in incidence between males and females, or between age groups. In cases where the cancer invaded into deeper stroma, the melanocytes were mainly observed in the normal epithelium around the carcinomas. Epithelial and stromal elements of the melanotic mucosa commonly showed hyperplastic changes such as acanthosis or basal cell hyperplasia, and chronic oesophagitis. Melanocytes were observed most commonly in the lower part of the oesophagus, the site where malignant melanoma of the oesophagus, most often originates. These results strongly suggest that the melanocyte increase observed in areas of hyperplastic epithelium and chronic oesophagitis may play an important role as a precursor lesion for malignant melanoma in the oesophagus. Springer-Verlag, 1990 Melanocytes nationallicence Melanoma nationallicence Oesophagus nationallicence Oesophageal neoplasms nationallicence Melanosis nationallicence Ohashi Kenichi 2nd Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113, Tokyo, Japan aut Kato Yo Department of Pathology, Cancer Institute, 1-37-1, Kami-Ikebukuro, Toshima-ku, 170, Tokyo, Japan aut Kanno Jun 2nd Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113, Tokyo, Japan aut Kasuga Tsutomu 2nd Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113, Tokyo, Japan aut Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 137-143 0174-7398 417:2<137 1990 417 428 https://doi.org/10.1007/BF02190531 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02190531 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohashi Kenichi 2nd Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Kato Yo Department of Pathology, Cancer Institute, 1-37-1, Kami-Ikebukuro, Toshima-ku, 170, Tokyo, Japan aut NATIONALLICENCE 700 1- Kanno Jun 2nd Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Kasuga Tsutomu 2nd Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113, Tokyo, Japan aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 137-143 0174-7398 417:2<137 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer