caa a22 4500 465754198 CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02190529 doi (NATIONALLICENCE)springer-10.1007/BF02190529 Radioprotection of minipig salivary glands by orciprenaline-carbachol [Elektronische Daten] An ultrastructural and semiquantitative light microscopic study [Suzanne Lotz, Jörg Caselitz, Holger Tschakert, Wolfgang Rehpenning, Gerhard Seifert] Summary: Parotid and submandibular glands of miniature pigs were exposed to 36 Gy X-irradiation given as 6×6 Gy in 3 weeks. Half of the animals received orciprenaline and carbachol before each dose. The effects were analysed 6 months later by light and electron microscopy. Ultrastructural examination showed less change in the pretreated glands. Semi-quantitative light microscopic data confirmed the significance of the differences. Acinar cells of both glands were significantly more numerous (P<0.01) and the cells were better preserved (P<0.01) in the pretreated group. The effect was more pronounced in the parotid gland, which appeared almost normal. Intercalated ducts of the parotid glands (P<0.01) and striated ducts of the submandibular glands (P<0.05) showed less change in pretreated animals. The findings confirm the radioprotective effect of pharmacologically induced degranulation of acinar cells. The biological effects of the radiation schedule (cumulative radiation effect value 18.76) as well as the dosage of orciprenaline and carbachol are within the normal range of medical treatment. Similar results may be expected from future studies in man. Springer-Verlag, 1990 Salivary glands nationallicence Radiation injury nationallicence Radioprotective substances nationallicence Miniature swine nationallicence Lotz Suzanne Abteilung für Pathologie, Allgemeines Krankenhaus Altona, Paul-Ehrlich-Strasse 1, D-2000, Hamburg 50, Germany aut Caselitz Jörg Abteilung für Pathologie, Allgemeines Krankenhaus Altona, Paul-Ehrlich-Strasse 1, D-2000, Hamburg 50, Germany aut Tschakert Holger Abteilung für Radiologie, Knappschaftskrankenhaus Bardenberg, Würselen, Germany aut Rehpenning Wolfgang Institut für Mathematik und Datenverarbeitung in der Medizin, Universität Hamburg, Hamburg, Germany aut Seifert Gerhard Institut für Pathologie, Universität Hamburg, Hamburg, Germany aut Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 119-128 0174-7398 417:2<119 1990 417 428 https://doi.org/10.1007/BF02190529 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02190529 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lotz Suzanne Abteilung für Pathologie, Allgemeines Krankenhaus Altona, Paul-Ehrlich-Strasse 1, D-2000, Hamburg 50, Germany aut NATIONALLICENCE 700 1- Caselitz Jörg Abteilung für Pathologie, Allgemeines Krankenhaus Altona, Paul-Ehrlich-Strasse 1, D-2000, Hamburg 50, Germany aut NATIONALLICENCE 700 1- Tschakert Holger Abteilung für Radiologie, Knappschaftskrankenhaus Bardenberg, Würselen, Germany aut NATIONALLICENCE 700 1- Rehpenning Wolfgang Institut für Mathematik und Datenverarbeitung in der Medizin, Universität Hamburg, Hamburg, Germany aut NATIONALLICENCE 700 1- Seifert Gerhard Institut für Pathologie, Universität Hamburg, Hamburg, Germany aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 119-128 0174-7398 417:2<119 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer