caa a22 4500 465754201 CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02190526 doi (NATIONALLICENCE)springer-10.1007/BF02190526 Immunohistochemical study of ependymal neoplasms: histological subtypes and glial and epithelial characteristics [Elektronische Daten] [Yoichi Kaneko, Iwao Takeshita, Toshio Matsushima, Toru Iwaki, Takatoshi Tashima, Masashi Fukui] Summary: An immunohistochemical study on ependymal tumours was performed in order to determine what relationships exist between histological subtypes and epithelial or glial characteristics. Thirty-eight ependymal tumours were examined with antibodies to cytokeratin (CK), epithelial membrane antigen (EMA), transthyretin (TTR) and glial fibrillary acidic protein (GFAP) using the avidin-biotin-complex technique. They included 23 ependymomas, 13 anaplastic ependymomas, and 2 myxopapillary ependymomas. Only 3 of the 23 ependymomas were positive with EMA but 19 reacted with GFAP. None of them were positive with CK. Six of the 13 anaplastic ependymomas were positive with EMA, 3 with CK and 10 with GFAP. Five of the 6 anaplastic ependymomas which had epithelial marker proteins were either negative or weakly positive for GFAP. The present study demonstrates that most benign ependymomas exhibit GFAP positivity while the anaplastic ones tend to suppress their glial nature in favour of epithelial differrentiation. However, ependymal tumours showed few characteristics of choroid plexus cells; only one of the examined cases was positive for TTR. Springer-Verlag, 1990 Cytokeratin nationallicence Ependymal tumour nationallicence Epithelial membrane antigen nationallicence Glial fibrillary acidic protein nationallicence Immunohistochemical study nationallicence Transthyretin nationallicence Kaneko Yoichi Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, 60 Maidashi 3-1-1, Higashi-ku, 812, Fukuoka, Japan aut Takeshita Iwao Department of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University, 60 Maidashi 3-1-1, Higashi-ku, 812, Fukuoka, Japan aut Matsushima Toshio Department of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University, 60 Maidashi 3-1-1, Higashi-ku, 812, Fukuoka, Japan aut Iwaki Toru Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, 60 Maidashi 3-1-1, Higashi-ku, 812, Fukuoka, Japan aut Tashima Takatoshi Department of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University, 60 Maidashi 3-1-1, Higashi-ku, 812, Fukuoka, Japan aut Fukui Masashi Department of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University, 60 Maidashi 3-1-1, Higashi-ku, 812, Fukuoka, Japan aut Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 97-103 0174-7398 417:2<97 1990 417 428 https://doi.org/10.1007/BF02190526 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02190526 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kaneko Yoichi Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, 60 Maidashi 3-1-1, Higashi-ku, 812, Fukuoka, Japan aut NATIONALLICENCE 700 1- Takeshita Iwao Department of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University, 60 Maidashi 3-1-1, Higashi-ku, 812, Fukuoka, Japan aut NATIONALLICENCE 700 1- Matsushima Toshio Department of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University, 60 Maidashi 3-1-1, Higashi-ku, 812, Fukuoka, Japan aut NATIONALLICENCE 700 1- Iwaki Toru Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, 60 Maidashi 3-1-1, Higashi-ku, 812, Fukuoka, Japan aut NATIONALLICENCE 700 1- Tashima Takatoshi Department of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University, 60 Maidashi 3-1-1, Higashi-ku, 812, Fukuoka, Japan aut NATIONALLICENCE 700 1- Fukui Masashi Department of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University, 60 Maidashi 3-1-1, Higashi-ku, 812, Fukuoka, Japan aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 97-103 0174-7398 417:2<97 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer