caa a22 4500 46575421X CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02190534 doi (NATIONALLICENCE)springer-10.1007/BF02190534 Deposition and remodelling of elastic fibres in chronic hepatitis [Elektronische Daten] [P. Bedossa, G. Lemaigre, F. Paraf, E. Martin] Summary: A longitudinal study of elastic fibres was conducted in liver biopsies from 21 patients with chronic viral hepatitis. Biopsies were taken at the start of treatment with alpha-interferon, and after 6 months or 1 year of treatment. No elastic fibres could be detected in portal tracts or fibrous septa when inflammation and necrosis were present, whatever the duration of the disease. Once the liver lesions had healed, elastic fibres were synthesized. Fibres were of two types and patterns: at first, they were thin, long and parallel to each other. Later, they were thicker, shorter and tortuous and were closely wrapped around thick bundles of collagen fibres. These findings suggest that the deposition of elastic fibres acts as a marker of healing in chronic active hepatitis and that their remodelling occurs concomitantly with the deposit of large bundles of collagen fibres. Springer-Verlag, 1990 Elastic fibre nationallicence Chronic hepatitis nationallicence Liver nationallicence Extracellular matrix nationallicence Bedossa P. Department of Pathology, H++ôpital A Béclére, Clamart, France aut Lemaigre G. Department of Pathology, H++ôpital A Béclére, Clamart, France aut Paraf F. Department of Pathology, H++ôpital A Béclére, Clamart, France aut Martin E. Department of Pathology, H++ôpital de BicÊtre, Le Kremlin-BicÊtre, France aut Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 159-162 0174-7398 417:2<159 1990 417 428 https://doi.org/10.1007/BF02190534 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02190534 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bedossa P. Department of Pathology, H++ôpital A Béclére, Clamart, France aut NATIONALLICENCE 700 1- Lemaigre G. Department of Pathology, H++ôpital A Béclére, Clamart, France aut NATIONALLICENCE 700 1- Paraf F. Department of Pathology, H++ôpital A Béclére, Clamart, France aut NATIONALLICENCE 700 1- Martin E. Department of Pathology, H++ôpital de BicÊtre, Le Kremlin-BicÊtre, France aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 159-162 0174-7398 417:2<159 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer