caa a22 4500 465754252 CHVBK 20180323111842.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02190530 doi (NATIONALLICENCE)springer-10.1007/BF02190530 Lyme carditis in immunodeficient mice during experimental infection of Borrelia burgdorferi [Elektronische Daten] [Gisela Zimmer, Ulrich Schaible, Michael Kramer, Gerhard Mall, Crisan Museteanu, Markus Simon] Summary: Recently, we described the severe combined immunodeficency (scid) mouse as a laboratory model forB. burgdorferi infection. Scid mice inoculated with the virulent low-passage tick isolateBorrelia burgdorferi ZS7 developed a severe pancarditis involving endocardium, myocardium and epicardium in the absence of functionalB- orT-cells. Soon after inoculation perivascular infiltration was observed, later diffuse infiltration of the interstitium of the subendocardial and subepicardial areas was seen. The infiltrate was mainly mononuclear and predominantly composed of Mac-1+ cells. Concomitantly, fibroblast proliferation and augmented collagen deposition occurred in the interstitium. This was associated with the presence ofB. burgdorferi organisms. The histopathological and ultrastructural findings observed in scid mice resemble those observed in human Lyme carditis. The data emphasize the suitability of the scid mouse as a model in which to study the role of the immune system in the pathogenesis of Lyme carditis. Springer-Verlag, 1990 Borrelia burgdorferi nationallicence Experimental infection nationallicence Mouse model nationallicence Immunodeficiency (scid) nationallicence Carditis nationallicence Zimmer Gisela Institut für Rechtsmedizin, Universität Heidelberg, Voss-Strasse 2, D-6900, Heidelberg, Germany aut Schaible Ulrich Max-Planck-Institut für Immunbiologie Freiburg, Germany aut Kramer Michael Hautklinik der Universität Heidelberg, Germany aut Mall Gerhard Institut für Pathologie Heidelberg, Germany aut Museteanu Crisan Max-Planck-Institut für Immunbiologie Freiburg, Germany aut Simon Markus Max-Planck-Institut für Immunbiologie Freiburg, Germany aut Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 129-135 0174-7398 417:2<129 1990 417 428 https://doi.org/10.1007/BF02190530 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02190530 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zimmer Gisela Institut für Rechtsmedizin, Universität Heidelberg, Voss-Strasse 2, D-6900, Heidelberg, Germany aut NATIONALLICENCE 700 1- Schaible Ulrich Max-Planck-Institut für Immunbiologie Freiburg, Germany aut NATIONALLICENCE 700 1- Kramer Michael Hautklinik der Universität Heidelberg, Germany aut NATIONALLICENCE 700 1- Mall Gerhard Institut für Pathologie Heidelberg, Germany aut NATIONALLICENCE 700 1- Museteanu Crisan Max-Planck-Institut für Immunbiologie Freiburg, Germany aut NATIONALLICENCE 700 1- Simon Markus Max-Planck-Institut für Immunbiologie Freiburg, Germany aut NATIONALLICENCE 773 0- Virchows Archiv A Springer-Verlag 417/2(1990-06-01), 129-135 0174-7398 417:2<129 1990 417 428 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer