caa a22 4500 465754791 CHVBK 20180323111844.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF01170013 doi (NATIONALLICENCE)springer-10.1007/BF01170013 The OASIS concept for predicting the biological activity of chemical compounds [Elektronische Daten] [O. Mekenyan, S. Karabunarlev, D. Bonchev] The existing QSAR approaches are critically assessed. The OASIS methodology is outlined as a generalization of the Hansch method. A large set of calculable geometric (topological, steric) and electronic indices is used to characterize molecular structure. The number of descriptors is reduced stepwise in a preliminary screening procedure, thus strongly diminishing the risk of a chance correlation. The non-formal parameters included in the ultimate mathematical model provide opportunities for shedding light on the biological interaction mechanism. Implemented as an IBM PC pack, the OASIS system is applied to various series of drugs, arriving at successful regression models. J.C. Baltzer AG, Scientific Publishing Company, 1990 Mekenyan O. Higher School of Chemical Technology, 8010, Burgas, Bulgaria aut Karabunarlev S. Higher School of Chemical Technology, 8010, Burgas, Bulgaria aut Bonchev D. Higher School of Chemical Technology, 8010, Burgas, Bulgaria aut Journal of Mathematical Chemistry Kluwer Academic Publishers 4/1(1990-12-01), 207-215 0259-9791 4:1<207 1990 4 10910 https://doi.org/10.1007/BF01170013 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01170013 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mekenyan O. Higher School of Chemical Technology, 8010, Burgas, Bulgaria aut NATIONALLICENCE 700 1- Karabunarlev S. Higher School of Chemical Technology, 8010, Burgas, Bulgaria aut NATIONALLICENCE 700 1- Bonchev D. Higher School of Chemical Technology, 8010, Burgas, Bulgaria aut NATIONALLICENCE 773 0- Journal of Mathematical Chemistry Kluwer Academic Publishers 4/1(1990-12-01), 207-215 0259-9791 4:1<207 1990 4 10910 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer