caa a22 4500 465757561 CHVBK 20180323111851.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00318378 doi (NATIONALLICENCE)springer-10.1007/BF00318378 A recessive mutant allele of the HNM1 gene of Saccharomyces cerevisiae is responsible for hyper-resistance to nitrogen mustard [Elektronische Daten] [Eckard Haase, Martin Brendel] Summary: A screening of haploid yeast strains for enhanced resistance to nitrogen mustard (HN2) yielded a recessive mutant allele, hnm1, that conferred hyper-resistance (HYR) to HN2. Diploids, homo- or heterozygous for the HNM1 locus, exhibit normal wild-type like resistance while homozygosity for hnm1 leads to the phenotype HYR to HN2. The hnm1 mutation could be found in yeast strains proficient or deficient in different DNA repair systems. In these mostly HN2-sensitive haploid repair-deficient mutants, hnm1 acted as a partial suppressor of HN2 sensitivity. All isolated recessive mutations conferring hyper-resistance belonged to a single complementations group. The HYR to HN2 phenotype was maximally expressed in growing cells and was associated with reduced mutability by HN2. HNM1 most probably controls uptake of HN2 which would be impaired in the hnm1 mutants. Springer-Verlag, 1990 Mutagen hyper-resistance nationallicence Nitrogen mustard nationallicence Saccharomyces cerevisiae nationallicence Haase Eckard Institut für Mikrobiologie der J.W. Goethe-Universität, Theodor-Stern-Kai 7, Haus 75, D-6000, Frankfurt/Main, Federal Republic of Germany aut Brendel Martin Institut für Mikrobiologie der J.W. Goethe-Universität, Theodor-Stern-Kai 7, Haus 75, D-6000, Frankfurt/Main, Federal Republic of Germany aut Current Genetics Springer-Verlag 18/3(1990-10-01), 187-192 0172-8083 18:3<187 1990 18 294 https://doi.org/10.1007/BF00318378 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00318378 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Haase Eckard Institut für Mikrobiologie der J.W. Goethe-Universität, Theodor-Stern-Kai 7, Haus 75, D-6000, Frankfurt/Main, Federal Republic of Germany aut NATIONALLICENCE 700 1- Brendel Martin Institut für Mikrobiologie der J.W. Goethe-Universität, Theodor-Stern-Kai 7, Haus 75, D-6000, Frankfurt/Main, Federal Republic of Germany aut NATIONALLICENCE 773 0- Current Genetics Springer-Verlag 18/3(1990-10-01), 187-192 0172-8083 18:3<187 1990 18 294 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer