caa a22 4500 465757707 CHVBK 20180323111851.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00318379 doi (NATIONALLICENCE)springer-10.1007/BF00318379 The recombinational hot spot mutation ade6-M26 of Schizosaccharomyces pombe stimulates recombination at sites in a nearby interval [Elektronische Daten] [C. Grimm, P. Munz, J. Kohli] Summary: With the help of in vitro constructed intragenic double mutants, we investigated the influence of the recombinational hot spot mutation ade6-M26 on meiotic recombination between two additional ade6 mutations proximal to it. Recombination was stimulated four-fold when M26 was present in a heterozygous condition and ten-fold when homozygous. M26 itself remained unaffected in a substantial number of these events. This indicates that the stimulation can not only be due to a preferred conversion of M26 to wild-type with co-conversion of the second mutation in cis. A model is proposed in which M26 acts as an "entry site” for recombinational enzymes. Springer-Verlag, 1990 Schizosaccharomyces pombe nationallicence M26 mutation nationallicence Intragenic recombination nationallicence Conversion nationallicence Grimm C. Institute of General Microbiology, University of Bern, Baltzerstrasse 4, CH-3012, Bern, Switzerland aut Munz P. Institute of General Microbiology, University of Bern, Baltzerstrasse 4, CH-3012, Bern, Switzerland aut Kohli J. Institute of General Microbiology, University of Bern, Baltzerstrasse 4, CH-3012, Bern, Switzerland aut Current Genetics Springer-Verlag 18/3(1990-10-01), 193-197 0172-8083 18:3<193 1990 18 294 https://doi.org/10.1007/BF00318379 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00318379 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grimm C. Institute of General Microbiology, University of Bern, Baltzerstrasse 4, CH-3012, Bern, Switzerland aut NATIONALLICENCE 700 1- Munz P. Institute of General Microbiology, University of Bern, Baltzerstrasse 4, CH-3012, Bern, Switzerland aut NATIONALLICENCE 700 1- Kohli J. Institute of General Microbiology, University of Bern, Baltzerstrasse 4, CH-3012, Bern, Switzerland aut NATIONALLICENCE 773 0- Current Genetics Springer-Verlag 18/3(1990-10-01), 193-197 0172-8083 18:3<193 1990 18 294 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer