caa a22 4500 46575774X CHVBK 20180323111852.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00318383 doi (NATIONALLICENCE)springer-10.1007/BF00318383 cpc-2 , a new locus involved in general control of amino acid synthetic enzymes in Neurospora crassa [Elektronische Daten] [Dirk Krüger, Jutta Koch, Ilse Barthelmess] Summary: In Neurospora crassa starvation for single amino acids leads to derepression of enzymes in many amino acid synthetic pathways. Regulation occurs at the level of transcription via "general amino acid (or cross-pathway) control”. In this paper a new regulatory gene, cpc-2, is described that specifies a positive, trans-acting effector involved in this control. This gene, located on linkage group VII, was identified by a recessive mutation, U142, which results in sensitivity for two amino acid analogues and a lack of enzyme derepression in response to amino acid limitation. It was shown that cpc-2 (U142) impairs the activation of transcription of amino acid structural genes in several biosyntheses. The only other known regulatory gene involved in general amino acid control of Neurospora is cpc-1. Transcription of the cpc-1 gene, however, is increased in response to amino acid starvation irrespective of the presence of the mutation U142. Springer-Verlag, 1990 Neurospora crassa nationallicence General amino acid control nationallicence cpc-2 nationallicence Krüger Dirk Institut für Angewandte Genetik, Universität Hannover, Herrenhäuser Strasse 2, D-3000, Hannover 21, Federal Republic of Germany aut Koch Jutta Institut für Angewandte Genetik, Universität Hannover, Herrenhäuser Strasse 2, D-3000, Hannover 21, Federal Republic of Germany aut Barthelmess Ilse Institut für Angewandte Genetik, Universität Hannover, Herrenhäuser Strasse 2, D-3000, Hannover 21, Federal Republic of Germany aut Current Genetics Springer-Verlag 18/3(1990-10-01), 211-215 0172-8083 18:3<211 1990 18 294 https://doi.org/10.1007/BF00318383 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00318383 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Krüger Dirk Institut für Angewandte Genetik, Universität Hannover, Herrenhäuser Strasse 2, D-3000, Hannover 21, Federal Republic of Germany aut NATIONALLICENCE 700 1- Koch Jutta Institut für Angewandte Genetik, Universität Hannover, Herrenhäuser Strasse 2, D-3000, Hannover 21, Federal Republic of Germany aut NATIONALLICENCE 700 1- Barthelmess Ilse Institut für Angewandte Genetik, Universität Hannover, Herrenhäuser Strasse 2, D-3000, Hannover 21, Federal Republic of Germany aut NATIONALLICENCE 773 0- Current Genetics Springer-Verlag 18/3(1990-10-01), 211-215 0172-8083 18:3<211 1990 18 294 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer