caa a22 4500 465761593 CHVBK 20180323111900.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF03000488 doi (NATIONALLICENCE)springer-10.1007/BF03000488 Combination cyclophosphamide and etoposide in treatment of small Cell Lung Cancer [Elektronische Daten] [W. Leung, W. Shiu, J. Pang] Thirty-one patients with histologically proven small cell lung cancer were treated with cyclophosphamide 1 gm-2 and etoposide (VP16-213) 125 mg m-2 both intravenously on day 1 followed by etoposide 250 mg m-2 orally on days 2-3 for a maximum of six courses at 3 weekly intervals. Fourteen patients had limited and 17 patients had extensive disease. Twenty-five patients were evaluable for response. Objective response was observed in 18 patients (58%) with 6 (19%) complete and 12 (39%) partial responses. Median survival of the entire group of patients was 30 weeks. There was significant survival benefit among the responders (P < 0.005) when compared with non-responders. One patient (3.3%) developed grade 4 while 60% of patients developed grade 1-2 haematological toxicity. Other side effects were relatively mild. We conclude that combination cyclophosphamide and etoposide was active in small cell lung cancer and relatively well tolerated. Humana Press Inc., 1990 Small cell lung cancer nationallicence Etoposide (VP16-213) nationallicence Cyclophosphamide nationallicence Leung W. Department of Clinical Oncology, Hong Kong aut Shiu W. Department of Clinical Oncology, Hong Kong aut Pang J. Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong aut Medical Oncology and Tumor Pharmacotherapy Humana Press 7/1(1990-03-01), 31-34 0736-0118 7:1<31 1990 7 12032 https://doi.org/10.1007/BF03000488 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03000488 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Leung W. Department of Clinical Oncology, Hong Kong aut NATIONALLICENCE 700 1- Shiu W. Department of Clinical Oncology, Hong Kong aut NATIONALLICENCE 700 1- Pang J. Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/1(1990-03-01), 31-34 0736-0118 7:1<31 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer