caa a22 4500 465761607 CHVBK 20180323111900.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF03000491 doi (NATIONALLICENCE)springer-10.1007/BF03000491 Cumulative Bone Marrow Tromal damage caused by X-Irradiation and Cytosine-Arabinoside in Leukemic mice [Elektronische Daten] [Zina Ben-ishay, Gregor Prindull, Sara Yankelev, Sara Sharon] A study of treated murine acute myeioid leukemia (AML) with an emphasis on the bone marrow stromal function is reported. Leukemia was induced in C57BI mice through intraperitoneal (i.p.) inoculation of C-1498 myelogenous leukemic cells. The leukemic mice were administered: (1) total body lethal X-irradiation (t.b.i); (2) two i.p. cytosine-arabinoside (Ara-C) injections followed by X-irradiation. Control mice received similar regimens. Bone marrow of experimental and control mice was processed for stromal cell cultures (SCC) andin vitro engraftment of hematopoietic cells onto the cultures. The results of this study indicate that the bone marrow stromal deficiency which occurs in leukemia is aggravated by Ara-C and irradiation treatments. Moreover, SCC of treated leukemic mice sustainin vitro hematopoiesis only to a limited degree. Stromal deficiency, as possible cause for graft failure in bone marrow transplanted leukemic patients, is discussed. Humana Press Inc., 1990 Bone-marrow stroma nationallicence Murine acute myeloid leukemia nationallicence Cytosine-arabinoside nationallicence X-irradiation nationallicence Ben-ishay Zina Laboratory of Experimental Hematology and Department of Anatomy & Embryology, Hebrew University-Hadassah Medical School, Jerusalem, Israel aut Prindull Gregor Department of Pediatrics, University of Göttingen, D-3400, Göttingen, Federal Republic of Germany aut Yankelev Sara Genetics Institute Inc., Cambridge., Massachusetts, USA aut Sharon Sara Laboratory of Experimental Hematology and Department of Anatomy & Embryology, Hebrew University-Hadassah Medical School, Jerusalem, Israel aut Medical Oncology and Tumor Pharmacotherapy Humana Press 7/1(1990-03-01), 55-59 0736-0118 7:1<55 1990 7 12032 https://doi.org/10.1007/BF03000491 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03000491 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ben-ishay Zina Laboratory of Experimental Hematology and Department of Anatomy & Embryology, Hebrew University-Hadassah Medical School, Jerusalem, Israel aut NATIONALLICENCE 700 1- Prindull Gregor Department of Pediatrics, University of Göttingen, D-3400, Göttingen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Yankelev Sara Genetics Institute Inc., Cambridge., Massachusetts, USA aut NATIONALLICENCE 700 1- Sharon Sara Laboratory of Experimental Hematology and Department of Anatomy & Embryology, Hebrew University-Hadassah Medical School, Jerusalem, Israel aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/1(1990-03-01), 55-59 0736-0118 7:1<55 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer