caa a22 4500 465761631 CHVBK 20180323111901.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF03000485 doi (NATIONALLICENCE)springer-10.1007/BF03000485 Topoisomerases, New Targets in Cancer Chemotherapy [Elektronische Daten] [J. Zijlstra, S. DE Jong, E. DE Vries, N. Mulder] The enzymes involved in the regulation of the three-dimensional structure of DNA, topoisomerase I and II, are important for the handling of DNA during vital cellular processes such as translation, transcription and mitosis. The enzymes are currently being studied intensively, they are being biochemically characterized and their mechanism of action is now better understood. Empirically discovered antitumor drugs appear to interfere with these enzymes, especially topoisomerase II. The DNA-topoisomerase II complex, which is an intermediate in the normal enzyme pathway, is stabilized by the drug and forms a ‘cleavable complex', which appears to be cytotoxic. The drugs involved are, e.g. anthra-cyclines, epipodophyllotoxins and acridines. The central role of this enzyme offers the cell an opportunity for the development of resistance by down-regulation of this enzyme or the production of resistant mutants, provided the adaptation does not hamper other vital cell functions. Knowledge of the working mechanism and the cellular regulation of the topoisomerases might lead to the selection of most effective drugs and treatment schedules, and to circumvention of drug resistance. Humana Press Inc., 1990 Topoisomerase nationallicence Drug resistance nationallicence Zijlstra J. Department of Internal Medicine, University Hospital Groningen, The Netherlands aut DE Jong S. Department of Internal Medicine, University Hospital Groningen, The Netherlands aut DE Vries E. Department of Internal Medicine, University Hospital Groningen, The Netherlands aut Mulder N. Department of Internal Medicine, University Hospital Groningen, The Netherlands aut Medical Oncology and Tumor Pharmacotherapy Humana Press 7/1(1990-03-01), 11-18 0736-0118 7:1<11 1990 7 12032 https://doi.org/10.1007/BF03000485 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03000485 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zijlstra J. Department of Internal Medicine, University Hospital Groningen, The Netherlands aut NATIONALLICENCE 700 1- DE Jong S. Department of Internal Medicine, University Hospital Groningen, The Netherlands aut NATIONALLICENCE 700 1- DE Vries E. Department of Internal Medicine, University Hospital Groningen, The Netherlands aut NATIONALLICENCE 700 1- Mulder N. Department of Internal Medicine, University Hospital Groningen, The Netherlands aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/1(1990-03-01), 11-18 0736-0118 7:1<11 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer