caa a22 4500 465761658 CHVBK 20180323111901.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02988545 doi (NATIONALLICENCE)springer-10.1007/BF02988545 Kromhout Daan Department of Epidemiology, National Institute of Public Health and Environmental Protection, P.O. Box 1, 3720, Bilthoven, BA, The Netherlands aut The importance of N-6 and N-3 fatty acids in carcinogenesis [Elektronische Daten] [Daan Kromhout] Cross-cultural comparisons show that total fat intake is related to breast and colon cancer mortality. Total fat consists of different fatty acid families. Therefore different fatty acids should be studied in relation to breast and colon carcinogenesis. Animal experiments suggest that N-6 polyunsaturated fatty acids may have a tumor promoting effect and that N-3 polyunsaturated fatty acids may exert an inhibitory effect on chemically-induced mammary and colon tumorigenesis. Data from epidemiologic studies in this area are scarce. Comparisons between Japan and Iceland and between Eskimos and Danes suggest that a low-fat diet in combination with a N-3/N-6 polyunsaturated fatty acid ratio of about 0.5 seems to be associated with low mortality rates from breast and colon cancer. Much more research is needed to determine the optimal intake of total fat, N-6 and N-3 polyunsaturated fatty acids in relation to breast and colon cancer prevention. Humana Press Inc., 1990 N-6 polyunsaturated fatty acids nationallicence N-3 polyunsaturated fatty acids nationallicence Breast cancer nationallicence Colon cancer nationallicence Animal experiments nationallicence Epidemiology nationallicence Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 173-176 0736-0118 7:2-3<173 1990 7 12032 https://doi.org/10.1007/BF02988545 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02988545 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Kromhout Daan Department of Epidemiology, National Institute of Public Health and Environmental Protection, P.O. Box 1, 3720, Bilthoven, BA, The Netherlands aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 173-176 0736-0118 7:2-3<173 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer