caa a22 4500 465761666 CHVBK 20180323111901.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02988543 doi (NATIONALLICENCE)springer-10.1007/BF02988543 Cancer chemoprevention by supplemental carotenoids and synergism with retinol in mastodynia treatment [Elektronische Daten] [Leonida Santamaria, Amalia Santamaria] Cancer chemoprevention with beta-carotene (BC), canthaxanthin (CX) and retinol-BC is reported with respect to skin, breast, gastric, colon carcinogeneses induced by benzo(a)pyrene (BP) with or without ultra violet radiation (UV-A, UV-B), dimethylbenzathracene (DMBA) ± UVB, P-UVA, N-methyl-N'-N-nitro-nitrosoguanidine (MNNG), dimethylhydrazine (DMH), and with respect to transplanted tumours. When animals were loaded with carotenoid supplementation one month before the carcinogenic induction (continued throughout the experiment), cancer prevention was observed up to 60-100%. The absence of provitamin A-activity in CX shows the carotenoid antioxidant property. Fifteen patients given BC + CX to prevent recurrences after radical removal of the primary neoplasia in organs like lung, breast, colon, urinary bladder, head and neck were studied in 1980-89. A longer than expected disease-free interval was preliminarily found. Supplemention of BC ± retinol was also reported to prevent and treat oral leucoplakia. Supplementation and intermittent retinol administration was also tested in benign cyclical mastalgia with clear cut side effect free therapeutic results. Humana Press Inc., 1990 Cancer chemoprevention nationallicence Human nationallicence Carotenoids nationallicence Vitamin A nationallicence Breast pain nationallicence Leukoplakia nationallicence Santamaria Leonida ‘ Camillo Golgi' Institute of General Pathology, Centro Tumori, 27100, Pavia, Italy aut Santamaria Amalia ‘ Camillo Golgi' Institute of General Pathology, Centro Tumori, 27100, Pavia, Italy aut Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 153-167 0736-0118 7:2-3<153 1990 7 12032 https://doi.org/10.1007/BF02988543 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02988543 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Santamaria Leonida ‘ Camillo Golgi' Institute of General Pathology, Centro Tumori, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Santamaria Amalia ‘ Camillo Golgi' Institute of General Pathology, Centro Tumori, 27100, Pavia, Italy aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 153-167 0736-0118 7:2-3<153 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer