caa a22 4500 465761682 CHVBK 20180323111901.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02988542 doi (NATIONALLICENCE)springer-10.1007/BF02988542 Hiatt Robert Division of Research, Kaiser Permanente Medical Care Program, 94611-5463, Oakland, California, USA aut Alcohol consumption and breast cancer [Elektronische Daten] [Robert Hiatt] Epidemiologic studies of the relationship of alcohol consumption and breast cancer are generally in support of a direct association, although they are not entirely consistent. Studies supporting this finding have come from many countries around the world and from many investigators working with different study designs and types of populations. Ten of 16 case-control studies, and five of six cohort studies have produced results supporting a positive association. When evaluated together through techniques such as meta-analysis, these studies suggest that there is a 50% increase in breast cancer risk for women who average between one and two drinks per day. All types of alcoholic beverages seem to increase the risk, but there is little agreement between studies on dose-response relationships. No biologic explanation for alcohol's possible role in breast carcinogenesis is yet known, but several hypotheses have been advanced. In the absence of any effective method of primary breast cancer prevention, and because current risk factors explain so little of the incidence of this common cancer, alcohol consumption is of potential importance from both public health and etiologic perspectives. The possible protective effect of moderate alcohol consumption on heart disease should be considered when assessing the risks of this level of consumption on breast cancer. Humana Press Inc., 1990 Alcohol drinking nationallicence Breast neoplasms nationallicence Cohort studies nationallicence Epidemiology nationallicence Meta-analysis nationallicence Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 143-151 0736-0118 7:2-3<143 1990 7 12032 https://doi.org/10.1007/BF02988542 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02988542 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hiatt Robert Division of Research, Kaiser Permanente Medical Care Program, 94611-5463, Oakland, California, USA aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 143-151 0736-0118 7:2-3<143 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer