caa a22 4500 465761690 CHVBK 20180323111901.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02988544 doi (NATIONALLICENCE)springer-10.1007/BF02988544 Conjugated dienoic derivatives of linoleic acid: A new class of anticarcinogens [Elektronische Daten] [Michael Pariza, Yeong Ha] Evidence establishing the anticarcinogenic activity of the conjugated dienoic derivatives of linoleic acid (CLA) is reviewed. Our findings demonstrate that CLA is a potent antioxidant and that the c-9,t-11 CLA isomer is selectively incorporated into cellular phospholipid, which may at least in part explain the anticarcinogenic activity of CLA. Dietary sources of CLA include grilled beef, cheese, and related foods. Another source of CLA is its endogenous generation via the carbon centered free radical oxidation of linoleic acid. We propose that the formation and action of CLA represents a previously unrecognizedin situ defense mechanism against membrane attack by oxygen radicals. Humana Press Inc., 1990 Anticarcinogen nationallicence Antioxidant nationallicence Fatty acids nationallicence Linoleic acid nationallicence Conjugated diene nationallicence Pariza Michael Food Research Institute, University of Wisconsin-Madison, 1925 Willow Drive, 53706, Madison, WI, USA aut Ha Yeong Food Research Institute, University of Wisconsin-Madison, 1925 Willow Drive, 53706, Madison, WI, USA aut Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 169-171 0736-0118 7:2-3<169 1990 7 12032 https://doi.org/10.1007/BF02988544 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02988544 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pariza Michael Food Research Institute, University of Wisconsin-Madison, 1925 Willow Drive, 53706, Madison, WI, USA aut NATIONALLICENCE 700 1- Ha Yeong Food Research Institute, University of Wisconsin-Madison, 1925 Willow Drive, 53706, Madison, WI, USA aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 169-171 0736-0118 7:2-3<169 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer