caa a22 4500 465761739 CHVBK 20180323111901.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02988536 doi (NATIONALLICENCE)springer-10.1007/BF02988536 Willett Walter Departments of Epidemiology and Nutrition, Harvard School of Public Health, and the Channing Laboratory, Boston, Massachusetts, USA aut Epidemiologic studies of diet and cancer [Elektronische Daten] [Walter Willett] Correlational studies comparing national diets with mortality rates of colon and breast cancer indicate very strong associations, on the order of correlation coefficients = +0.8, between intake of meat or animal fat and rates of both these cancers. However, both case-control and prospective cohort studies have found little positive association between these dietary factors and risk of breast cancer. This lack of a positive association, at least in the largest prospective study, cannot be explained by insufficient variability in diet in the study population or by imprecision in the dietary questionnaire, although it is possible that the latent period between dietary intake and diagnosis of breast cancer is so long that an effect of fat intake could not be seen. However, the normal risk of breast cancer in Seventh-Day Adventists and vegetarian nuns, the small increase in breast cancer rates in Japan since World War II despite a 2.5-fold increase in fat intake, and the lack of correlation between fat intake and risk of breast cancer mortality among rural Chinese populations all suggest that a major association between meat and animal fat intake and risk of breast cancer is unlikely or weak. In contrast, the striking international correlations between intake of meat and animal fat and colon cancer rates are generally supported by case-control and cohort studies. In particular, associations between intake of red meat and colon cancer have been seen in many, although not all, of these studies. Data on fibre intake, a putative preventive factor, are less clear; intake of fruits and vegetables has been quite consistently associated with a lower risk, but consumption of a grain fiber has generally been associated with either an excess or no increase in risk. Humana Press Inc., 1990 Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 93-97 0736-0118 7:2-3<93 1990 7 12032 https://doi.org/10.1007/BF02988536 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02988536 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Willett Walter Departments of Epidemiology and Nutrition, Harvard School of Public Health, and the Channing Laboratory, Boston, Massachusetts, USA aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 93-97 0736-0118 7:2-3<93 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer