caa a22 4500 465761771 CHVBK 20180323111901.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02988548 doi (NATIONALLICENCE)springer-10.1007/BF02988548 Diplock Anthony Division of Biochemistry, United Medical and Dental Schools (University of London), Guy's Hospital, SEI 9RT, London, U.K aut Mineral insufficiency and cancer [Elektronische Daten] [Anthony Diplock] There are excellent theoretical reasons why the mineral nutrients selenium, manganese, copper and zinc, known as the antioxidant minerals, may be involved in the prevention of cancer aetiogenesis. The biochemistry is discussed of the part played by the antioxidant minerals, in the wider context of the other dietary antioxidants vitamins A, E and C, and beta carotene, in preventing tissue damage caused by activated metabolites of oxygen. The likely part played by these oxygen metabolites is described and a detailed review given of the evidence that suggests a role for antioxidant minerals, notably selenium, in preventing carcinogenesis in a range of animal models. There follows a summary of the emerging epidemiological evidence that suggests clearly that low selenium intake is a risk factor in the aetiology of human cancer. Humana Press Inc., 1990 Cancer nationallicence Trace minerals nationallicence Selenium nationallicence Copper/zinc nationallicence Manganese nationallicence Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 193-198 0736-0118 7:2-3<193 1990 7 12032 https://doi.org/10.1007/BF02988548 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02988548 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Diplock Anthony Division of Biochemistry, United Medical and Dental Schools (University of London), Guy's Hospital, SEI 9RT, London, U.K aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 193-198 0736-0118 7:2-3<193 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer