caa a22 4500 465761798 CHVBK 20180323111901.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02988547 doi (NATIONALLICENCE)springer-10.1007/BF02988547 Experimental approaches to nutrition and cancer: Fats, calories, vitamins and minerals [Elektronische Daten] [Robert Good, Ellen Lorenz, Robert Engelman, Noorbibi Day] Chronic energy intake restriction (CEIR) inhibits lymphoproliferative disease, autoimmune-based renal disease and mammary adenocarcinoma in mice of numerous short-lived strains (MRL/1pr, C3H/Bi, C3H/Ou). Doubling and tripling of life span and health span and inhibition of development of diseases associated with aging could be attributed to restriction of calories but not to restriction of dietary fat in the absence of calorie restriction. In mice of both long- and short-lived strains, CEIR dramatically prevents the waning of immunologic vigor that commonly occurs with aging, delays thymic involution, impairs formation of circulating immune complexes, prevents the renal injury that accompanies autoimmune disease, and significantly forestalls development of genetically determined lymphoproliferative or neoplastic disease. Evidence suggests that CEIR may exert these beneficial influences in part through regulation of cellular proliferation. Trace elements, particularly zinc, as well as vitamins may play important roles in maintaining immunocompetence and also appear to be of significance in the dietary prevention of certain experimental cancers. Humana Press Inc., 1990 Calorie restriction nationallicence Mammary adenocarcinoma nationallicence Proliferation nationallicence Zinc nationallicence Good Robert Department of Pediatrics, All Children's Hospital, University of South Florida, 33701, St. Petersburg, Florida, USA aut Lorenz Ellen Department of Pediatrics, All Children's Hospital, University of South Florida, 33701, St. Petersburg, Florida, USA aut Engelman Robert Department of Pediatrics, All Children's Hospital, University of South Florida, 33701, St. Petersburg, Florida, USA aut Day Noorbibi Department of Pediatrics, All Children's Hospital, University of South Florida, 33701, St. Petersburg, Florida, USA aut Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 183-192 0736-0118 7:2-3<183 1990 7 12032 https://doi.org/10.1007/BF02988547 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02988547 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Good Robert Department of Pediatrics, All Children's Hospital, University of South Florida, 33701, St. Petersburg, Florida, USA aut NATIONALLICENCE 700 1- Lorenz Ellen Department of Pediatrics, All Children's Hospital, University of South Florida, 33701, St. Petersburg, Florida, USA aut NATIONALLICENCE 700 1- Engelman Robert Department of Pediatrics, All Children's Hospital, University of South Florida, 33701, St. Petersburg, Florida, USA aut NATIONALLICENCE 700 1- Day Noorbibi Department of Pediatrics, All Children's Hospital, University of South Florida, 33701, St. Petersburg, Florida, USA aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 183-192 0736-0118 7:2-3<183 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer