caa a22 4500 465761801 CHVBK 20180323111901.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02988534 doi (NATIONALLICENCE)springer-10.1007/BF02988534 Dietary carcinogens, environmental pollution, and cancer: Some misconceptions [Elektronische Daten] [Bruce Ames, Lois Gold] Various misconceptions about dietary carcinogens, pesticide residues, and cancer causation are discussed. The pesticides in our diet are 99.99% natural, since plants make an enormous variety of toxins against fungi, insects, and animal predators. Although only 50 of these natural pesticides have been tested in animal cancer tests, about half of them are carcinogens. About half of all chemicals tested in animal cancer tests are positive. The proportion of natural pesticides positive in animal tests of clastogenicity is also the same as for synthetic chemicals. It is argued that testing chemicals in animals at the maximum tolerated dose primarily measures chronic cell proliferation, a threshold process. Cell proliferation is mutagenic in several ways, including inducing mitotic recombination, and therefore chronic induction of cell proliferation is a risk factor for cancer. Humana Press Inc., 1990 Pesticides nationallicence Animal cancer tests nationallicence Cancer causation nationallicence Ames Bruce Division of Biochemistry and Molecular Biology, Barker Hall, University of California, 94720, Berkeley, CA, USA aut Gold Lois Division of Biochemistry and Molecular Biology, Barker Hall, University of California, 94720, Berkeley, CA, USA aut Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 69-85 0736-0118 7:2-3<69 1990 7 12032 https://doi.org/10.1007/BF02988534 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02988534 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ames Bruce Division of Biochemistry and Molecular Biology, Barker Hall, University of California, 94720, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Gold Lois Division of Biochemistry and Molecular Biology, Barker Hall, University of California, 94720, Berkeley, CA, USA aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 69-85 0736-0118 7:2-3<69 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer