caa a22 4500 465761828 CHVBK 20180323111901.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02988546 doi (NATIONALLICENCE)springer-10.1007/BF02988546 Stevens Richard Pacific Northwest Laboratory, 99352, Richland, WA, USA aut Iron and the risk of cancer [Elektronische Daten] [Richard Stevens] Four epidemiological studies have been performed that are generally consistent with the hypothesis that increased available body iron stores increase the risk of cancer or of general mortality. In a study based on the First National Health and Nutrition Examination Survey in the United States (NHANES), 232 men who developed cancer over a ten year period had a mean transferrin saturation of 33.1% at least 4 years before diagnosis, whereas 3,113 men who did not develop cancer had a transferrin saturation of 30.7% (p = 0.002). The hypothesis is based on two possible biological mechanisms. First, iron can catalyse the production of oxygen radicals and these may be proximate carcinogens. Second, iron may be a limiting nutrient to the growth and replication of a cancer cell. There are at least five areas of potential research related to iron and cancer based on these biological mechanisms: (1) etiology of cancer, (2) etiology of radiation-induced cancer, (3) prognosis after cancer diagnosis, (4) cancer risk resulting from therapy, and (5) interactions with other biochemical factors. An unexpected finding of the human studies done to date has been a highly significant negative association of serum albumin and long term cancer risk. Serum albumin is lower in smokers and older people, however, the negative association persists after controlling for these factors. Humana Press Inc., 1990 Cancer nationallicence Iron nationallicence Oxidative stress nationallicence Epidemiology nationallicence Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 177-181 0736-0118 7:2-3<177 1990 7 12032 https://doi.org/10.1007/BF02988546 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02988546 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Stevens Richard Pacific Northwest Laboratory, 99352, Richland, WA, USA aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/2-3(1990-06-01), 177-181 0736-0118 7:2-3<177 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer