caa a22 4500 465761844 CHVBK 20180323111901.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02987103 doi (NATIONALLICENCE)springer-10.1007/BF02987103 Induced hyperglycemia and tumor chemotherapy: Experimental and clinical studies [Elektronische Daten] [S. Osinsky, G. Evtushenko, E. Annin, L. Bubnovskaja] In order to clarify the influence of induced hyperglycemia upon antitumor effects of chemotherapy we studied some animal and human tumors. We observed that hyperglycemia enhances the antitumor effects of some cytostatic drugs several fold, due in part to the changes in the microphysiology induced by the hyperglycemia. Time doubling of some transplanted rat tumors and survival time of rats, rabbits and dogs bearing the transplanted and spontaneous tumors increased two to ten fold when the chemotherapy was used under hyperglycemia. Remission duration in patients with malignant brain glioma was enhanced by an average of six months; two years survival increased two-fold and the three years survival in patients with ovarian carcinoma in Stage III-IV increased two-fold; five years survival, 1.5-fold. The number of complications due to the combination of hyperglycemia and chemotherapy were not increased significantly. The problems of combination chemotherapy and hyperglycemia for oncologic patients' treatment are under discussion. Humana Press Inc., 1990 Hyperglycemia nationallicence Antitumor drugs nationallicence Tumor therapy nationallicence Osinsky S. R. E. Kavetsky Institute for Oncology Problems, Academy of Sciences of Ukrainian S.S.R., Vasilkovskaja Str. 45, 252022, Kiev-022, USSR aut Evtushenko G. R. E. Kavetsky Institute for Oncology Problems, Academy of Sciences of Ukrainian S.S.R., Vasilkovskaja Str. 45, 252022, Kiev-022, USSR aut Annin E. R. E. Kavetsky Institute for Oncology Problems, Academy of Sciences of Ukrainian S.S.R., Vasilkovskaja Str. 45, 252022, Kiev-022, USSR aut Bubnovskaja L. R. E. Kavetsky Institute for Oncology Problems, Academy of Sciences of Ukrainian S.S.R., Vasilkovskaja Str. 45, 252022, Kiev-022, USSR aut Medical Oncology and Tumor Pharmacotherapy Humana Press 7/4(1990-12-01), 249-256 0736-0118 7:4<249 1990 7 12032 https://doi.org/10.1007/BF02987103 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02987103 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Osinsky S. R. E. Kavetsky Institute for Oncology Problems, Academy of Sciences of Ukrainian S.S.R., Vasilkovskaja Str. 45, 252022, Kiev-022, USSR aut NATIONALLICENCE 700 1- Evtushenko G. R. E. Kavetsky Institute for Oncology Problems, Academy of Sciences of Ukrainian S.S.R., Vasilkovskaja Str. 45, 252022, Kiev-022, USSR aut NATIONALLICENCE 700 1- Annin E. R. E. Kavetsky Institute for Oncology Problems, Academy of Sciences of Ukrainian S.S.R., Vasilkovskaja Str. 45, 252022, Kiev-022, USSR aut NATIONALLICENCE 700 1- Bubnovskaja L. R. E. Kavetsky Institute for Oncology Problems, Academy of Sciences of Ukrainian S.S.R., Vasilkovskaja Str. 45, 252022, Kiev-022, USSR aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/4(1990-12-01), 249-256 0736-0118 7:4<249 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer