caa a22 4500 465761941 CHVBK 20180323111901.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02987100 doi (NATIONALLICENCE)springer-10.1007/BF02987100 Effect of amrinone on anthracycline-induced lethal and cardiac toxicity in mice and rats [Elektronische Daten] [F. Villani, C. Manzotti, M. Mella, E. Monti, G. Savi, F. Zunino] The protective role of amrinone against toxicity of anthracyclines was examined in both mice and rats. These two anthracyclincs were selected since they are characterized by different patterns of toxicity. In contrast to doxorubicin, the 4′-deoxy derivative did not cause delayed mortality. The results of this investigation indicate that amrinone is an effective protective agent against acute lethal events induced by both anthracyclines. However, the inotropic agent did not reduce the delayed mortality produced by doxorubicin. This parallels the apparent lack of prevention of doxorubicin-induced myocardial toxicity in CD rats, as determined by ECG changes and by morphologic alterations following multiple drug administrations. The administration of amrinone did not interfere with the antitumor activity of 4′-deoxy-doxorubicin against C-26 colon tumor. Humana Press Inc., 1990 Anthracyclines nationallicence Amrinone nationallicence Lethal toxicity nationallicence Cardiotoxicity nationallicence Villani F. Istituto Nazionale per lo Studio e La Cura dei Tumori, Milano aut Manzotti C. Istituto Nazionale per lo Studio e La Cura dei Tumori, Milano aut Mella M. Istituto Nazionale per lo Studio e La Cura dei Tumori, Milano aut Monti E. Department of Pharmacology, University of Milan, Italy aut Savi G. Istituto Nazionale per lo Studio e La Cura dei Tumori, Milano aut Zunino F. Istituto Nazionale per lo Studio e La Cura dei Tumori, Milano aut Medical Oncology and Tumor Pharmacotherapy Humana Press 7/4(1990-12-01), 227-232 0736-0118 7:4<227 1990 7 12032 https://doi.org/10.1007/BF02987100 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02987100 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Villani F. Istituto Nazionale per lo Studio e La Cura dei Tumori, Milano aut NATIONALLICENCE 700 1- Manzotti C. Istituto Nazionale per lo Studio e La Cura dei Tumori, Milano aut NATIONALLICENCE 700 1- Mella M. Istituto Nazionale per lo Studio e La Cura dei Tumori, Milano aut NATIONALLICENCE 700 1- Monti E. Department of Pharmacology, University of Milan, Italy aut NATIONALLICENCE 700 1- Savi G. Istituto Nazionale per lo Studio e La Cura dei Tumori, Milano aut NATIONALLICENCE 700 1- Zunino F. Istituto Nazionale per lo Studio e La Cura dei Tumori, Milano aut NATIONALLICENCE 773 0- Medical Oncology and Tumor Pharmacotherapy Humana Press 7/4(1990-12-01), 227-232 0736-0118 7:4<227 1990 7 12032 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer