caa a22 4500 46576259X CHVBK 20180323111903.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00300407 doi (NATIONALLICENCE)springer-10.1007/BF00300407 Intestinal endocrine cells in Hirschsprung's disease [Elektronische Daten] No reduction in density in aganglionic compared with ganglionic segment [L. Larsson, F. Sundler, R. Ekman] The aganglionic intestine in Hirschsprung's disease displays a severe neuronal derangement. The changes are particularly evident in the muscular innervation. In the gut the endocrine cells are among the cells known to be influenced by neurons. We have, therefore, examined the endocrine cells in ganglionic and aganglionic intestine using immunocytochemistry and immunochemistry. The endocrine cells were studied using antibodies against the neuroendocrine marker chromogranin A, the amine serotonin and the hormonal peptides somatostatin, glucagon/glicentin and peptide YY (PYY), thus covering virtually all endocrine cell types known to occur in this region. The PYY concentration in the mucosal layer was measured by radioimmunoassay. In ganglionic as well as in aganglionic intestine large populations of cells storing chromogranin A, serotonin, glucagon and PYY and a smaller population of somatostatin cells were seen. There was an increase in the density of these cells in the aganglionic intestine compared with ganglionic. The data indicate that the endocrine cell populations in the intestinal wall can be maintained despite severe derangements of the nerve supply. Springer-Verlag, 1990 Larsson L. Department of Pediatric Surgery, University Hospital, Lund, Sweden aut Sundler F. Department of Medical Cell Research, University Hospital, Lund, Sweden aut Ekman R. Department of Psychiatry and Neurochemistry, University Hospital, Lund, Sweden aut International Journal of Colorectal Disease Springer-Verlag 5/3(1990-08-01), 155-160 0179-1958 5:3<155 1990 5 384 https://doi.org/10.1007/BF00300407 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00300407 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Larsson L. Department of Pediatric Surgery, University Hospital, Lund, Sweden aut NATIONALLICENCE 700 1- Sundler F. Department of Medical Cell Research, University Hospital, Lund, Sweden aut NATIONALLICENCE 700 1- Ekman R. Department of Psychiatry and Neurochemistry, University Hospital, Lund, Sweden aut NATIONALLICENCE 773 0- International Journal of Colorectal Disease Springer-Verlag 5/3(1990-08-01), 155-160 0179-1958 5:3<155 1990 5 384 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer