caa a22 4500 465762689 CHVBK 20180323111903.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00300401 doi (NATIONALLICENCE)springer-10.1007/BF00300401 Growth hormone increases the bursting strength of colonic anastomoses [Elektronische Daten] An experimental study in the rat [H. Christensen, H. Oxlund, S. Laurberg] The effect of growth hormone on the bursting strength of left colonic anastomoses was investigated experimentally. Seventy-two 3 month-old female rats were randomized into two groups receiving daily injection of either saline (controls) or 2.0 mg biosynthetic human growth hormone per kg body weight per day. All injections were started 7 days before a left colonic resection and anastomosis, and continued until sacrifice at the 2nd, 4th or 6th post-operative day. The bursting strength of the anastomoses was tested in anaesthetized, living rats. The bursting pressure and the bursting wall tension of the growth hormone treated animals were increased two-fold on the second post-operative day (2p<0.005) and three-fold on the fourth post-operative day (2p<0.05), compared with controls. There was no difference in the bursting pressure or the bursting wall tension on the sixth postoperative day. The mass of the resected segment was incresed by the pre-operative growth hormone treatment, whereas the hydroxyproline content was unchanged. In conclusion, treatment with biosynthetic human growth hormone increases the strength of colonic anastomoses in the early phases of healing. Springer-Verlag, 1990 Christensen H. Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark aut Oxlund H. Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark aut Laurberg S. Institute of Experimental Clinical Research, University of Aarhus, Aarhus Kommunehospital, Aarhus, Denmark aut International Journal of Colorectal Disease Springer-Verlag 5/3(1990-08-01), 130-134 0179-1958 5:3<130 1990 5 384 https://doi.org/10.1007/BF00300401 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00300401 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Christensen H. Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark aut NATIONALLICENCE 700 1- Oxlund H. Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark aut NATIONALLICENCE 700 1- Laurberg S. Institute of Experimental Clinical Research, University of Aarhus, Aarhus Kommunehospital, Aarhus, Denmark aut NATIONALLICENCE 773 0- International Journal of Colorectal Disease Springer-Verlag 5/3(1990-08-01), 130-134 0179-1958 5:3<130 1990 5 384 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer