caa a22 4500 465762727 CHVBK 20180323111903.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00300404 doi (NATIONALLICENCE)springer-10.1007/BF00300404 Adenocarcinoma of the rectum treated by abdominoperineal excision: multivariate analysis of prognostic factors [Elektronische Daten] [M. Huguier, F. Depoux, S. Houry, S. Mauban] The aims of this study were to describe the results of 100 consecutive abdominoperineal excisions, and to try to define homogeneous subgroups of survivors using the Cox regression analysis model. There was one postoperative death. No patient was lost to follow-up. Overall 5-year survival rate was 45%. Multivariate analysis selected 3 prognostic factors: lymph node involvement (p<0.001), local tumour extent (P=0.08), and extension to adjacent organs (p=0.03). Four subgroups of patients were defined. Best survival was observed in patients (n=43) with tumour invading into the subserosa (W1) or less and without lymph node metastasis (N0), with a 5-year survival of 82% (group 1). Patients in Group 2 (n=18) had a tumour invading into the muscularis propria or less with lymph node metastasis (W0 N+), or into the serosa or perirectal fat without lymph node invasion (W2 N0), with a 5-year survival of 51%. Patients in Group 3 (n=17) had a tumour invading into the subserosa with lymph node invasion (W1 N+) or extension to adjacent organ without lymph node invasion (W3 N0) with a 5-year survival of 24%. Patients in group 4 (n=22) had extension into the serosa or perirectal fat or more with lymph node invasion (W2 N+) with a 5-year survival of 2%. This scoring system is simple, practical and easy to apply. If it can be confirmed by other studies, its routine adoption could be justified. Springer-Verlag, 1990 Huguier M. Department of Digestive Surgery, Hôpital Tenon, Paris, France aut Depoux F. Department of Digestive Surgery, Hôpital Tenon, Paris, France aut Houry S. Department of Digestive Surgery, Hôpital Tenon, Paris, France aut Mauban S. Department of Digestive Surgery, Hôpital Tenon, Paris, France aut International Journal of Colorectal Disease Springer-Verlag 5/3(1990-08-01), 144-147 0179-1958 5:3<144 1990 5 384 https://doi.org/10.1007/BF00300404 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00300404 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huguier M. Department of Digestive Surgery, Hôpital Tenon, Paris, France aut NATIONALLICENCE 700 1- Depoux F. Department of Digestive Surgery, Hôpital Tenon, Paris, France aut NATIONALLICENCE 700 1- Houry S. Department of Digestive Surgery, Hôpital Tenon, Paris, France aut NATIONALLICENCE 700 1- Mauban S. Department of Digestive Surgery, Hôpital Tenon, Paris, France aut NATIONALLICENCE 773 0- International Journal of Colorectal Disease Springer-Verlag 5/3(1990-08-01), 144-147 0179-1958 5:3<144 1990 5 384 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer